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品質水準
アッセイ
≥98% (HPLC)
フォーム
powder
色
white to beige
溶解性
DMSO: 20 mg/mL, clear
保管温度
2-8°C
SMILES記法
OC1=C(O)C=C(C(CSC#N)=O)C=C1
InChI
1S/C9H7NO3S/c10-5-14-4-9(13)6-1-2-7(11)8(12)3-6/h1-3,11-12H,4H2
InChI Key
SVFLBLCWKKQKDW-UHFFFAOYSA-N
アプリケーション
BIX has been used in cell viability assay.
生物化学的／生理学的作用
BIX (BiP protein inducer X) induces the expression of the endoplasmic reticulum chaperone protein GRP78 (glucose regulated protein 78, BiP) leading to an attenuation of the unfolded protein response. BIX protects neuronal cells and retinal cells from ER-stress induced cell death.
その他情報
air sensitive
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Skin Sens. 1
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SML1073-IP:
SML1073-BULK:
SML1073-25MG:
SML1073-5MG:
SML1073-VAR:
最新バージョンのいずれかを選択してください：
試験成績書（COA）
Lot/Batch Number
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X Xie et al.
Current molecular medicine, 18(1), 3-14 (2018-03-27)
Vascular network formation induced by angiogenesis plays an important role in many physiological and pathological processes. However, the role of blood flow and underlying mechanisms in vascular network formation, for example for the development of the caudal vein plexus (CVP)
Marta Kramer Mikkelsen et al.
BMC cancer, 18(1), 934-934 (2018-09-29)
Several intervention studies have demonstrated that exercise training has beneficial effects among cancer patients. However, older cancer patients are underrepresented in clinical trials, and only few exercise-based studies have focused specifically on older patients with cancer. In particular, research investigating the
Myungjin Jo et al.
Genome research, 27(9), 1487-1500 (2017-06-10)
To understand disease mechanisms, a large-scale analysis of human-yeast genetic interactions was performed. Of 1305 human disease genes assayed, 20 genes exhibited strong toxicity in yeast. Human-yeast genetic interactions were identified by en masse transformation of the human disease genes
Dana M Hardbower et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(5), E751-E760 (2017-01-18)
Macrophage activation is a critical step in host responses during bacterial infections. Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine metabolism, has been well studied in epithelial cells and is known to have essential roles in many different cellular functions.
Ling Xiao et al.
Circulation, 142(25), 2443-2455 (2020-10-24)
Ibrutinib is a Bruton tyrosine kinase inhibitor with remarkable efficacy against B-cell cancers. Ibrutinib also increases the risk of atrial fibrillation (AF), which remains poorly understood. We performed electrophysiology studies on mice treated with ibrutinib to assess inducibility of AF.
資料
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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