SML1232

cGAMP sodium salt

≥98% (HPLC)

• 別名: 3′3′-cGAMP sodium salt, Cyclic AMP-GMP sodium salt, c-GMP-AMP sodium salt, cyclic GMP-AMP sodium salt
• 実験式（ヒル表記法）: C₂₀H₂₄N₁₀O₁₃P₂ · xNa⁺
• CAS番号: 849214-04-6
• 分子量: 674.41 (free acid basis)
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825735
• NACRES: NA.77

特性

• 詳細: contains 0.5μmol of powder (approx. 0.335mg)
• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 保管温度: −20°C
• SMILES記法: O=C1N=C(N)NC2=C1N=CN2[C@H](O3)[C@H](O)[C@H](OP4(O)=O)[C@H]3COP(O)(O[C@H]5[C@@H](O)[C@H](N6C=NC7=C6N=CN=C7N)O[C@@H]5CO4)=O.C

詳細

アプリケーション

cGAMP sodium salt has been used in cGAS-cGAMP Activity Assay.

生物化学的／生理学的作用

Cyclic AMP-GMP (cGAMP) is one of several naturally occurring cyclic dinucleotides that act as a bacterial second messengers to regulate important signaling mechanisms in prokaryotes that control bacterial survival, adhesion, colonization, biofilm formation, and virulence factors production. In cholera c-AMP-GMP promotes intestinal colonization by down-regulating chemotaxis. During infections bacterial cGAMP is bound by host STING (stimulator of interferon genes) activating innate immune responses leading to expression of interferon genes.

cGAMP induces the formation of cytokines (interferon-β, interferon-γ), activation of dendritic cells and CD8⁺ T cell cross priming. Through this action, it promotes innate immune response. cGAMP possesses antitumor activity and is prefered for immunotherapy in cancer treatment.

調製ノート

Cyclic AMP-GMP is soluble in water and aqueous buffers (> 10 mM, limits have not been determined).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable