SML1277

Geldanamycin-FITC

≥98% (HPLC), from Streptomyces hygroscopicus

• 別名: Geldanamycin, fluorescein isothiocyanate labeled
• 実験式（ヒル表記法）: C₅₅H₆₃N₅O₁₃S
• 分子量: 1034.18
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 由来生物: Streptomyces hygroscopicus
• 品質水準: 200
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: protect from light
• 色: yellow to yellow-orange
• 溶解性: DMSO: soluble 5 mg/mL
• 抗生物質活性スペクトル: neoplastics
• 作用機序: enzyme | inhibits
• 保管温度: −20°C

詳細

詳細

Chemical structure: benzenoid

生物化学的／生理学的作用

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Geldanamycin-FITC is a fluorescent derivative of geldanamycin. It is used as a fluorescent tracer for heat shock protein 90 (HSP90) inhibitors in fluorescence polarization (FP) competition binding assay.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable