SML1664

Deoxynivalenol Ready Made Solution

1 mg/mL

• 別名: DON, ボミトキシン
• 実験式（ヒル表記法）: C₁₅H₂₀O₆
• CAS番号: 51481-10-8
• 分子量: 296.32
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 由来生物: Fusarium sp. (Fusarium asiaticum)
• 品質水準: 200
• 形状: solution (ethanol: 2-propanol 95:5)
• 保管条件: protect from light
• 濃度: 1 mg/mL
• 輸送温度: dry ice
• 保管温度: −20°C
• InChI: 1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
• InChI Key: LINOMUASTDIRTM-QGRHZQQGSA-N

詳細

生物化学的／生理学的作用

Deoxynivalenol (DON) is a trichothecene mycotoxin that inhibits the synthesis of DNA and RNA as well as protein synthesis at the ribosomal level. DON induces IL-6 mediated serum hyperelevation of IgA, as well as phosphorylation of extracellular signal regulated protein kinases 1 and 2 (ERK 1,2) and c-Jun N-terminal kinases 1 and 2 (JNK 1,2) in mice. An in vitro study with porcine ovarian granulosa cells suggests a dose dependent association of DON on porcine ovarian functions. It was also shown that LPS and its downstream mediators can interact with DON to modulate proliferative, cytotoxic and apoptotic outcomes in leukocytes in a tissue specific manner.

調製ノート

Deoxynivalenol ready-made solution (1 mg/ml in Ethanol: 2-propanol 95:5) can be diluted in aqueous buffers to a working concentration of 0.1-1 μg/ml (1:1000).

安全性情報

• ピクトグラム: GHS02,GHS07
• シグナルワード: Danger
• 危険有害性情報: H225,H319
• 注意書き: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Flam. Liq. 2
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 1
• 引火点(°F): 57.2 °F
• 引火点(℃): 14 °C