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由来生物
Penicillium sp.
アッセイ
≥98% (HPLC)
フォーム
powder
色
yellow to orange
保管温度
−20°C
SMILES記法
OC1=CC(C2=CC(OC)=CC(O)=C2C(O)=O)=C(C)C=C1O
InChI
1S/C15H14O6/c1-8-5-13(16)14(17)7-11(8)12-6-9(20-2)3-4-10(12)15(18)21-19/h3-7,16-17,19H,1-2H3
InChI Key
GWGIZSANXIQQQR-UHFFFAOYSA-N
生物化学的／生理学的作用
Altenusin, a non-steroidal fungal metabolite, is a potent and selective agonist of Farnesoid X receptor (FXR) that protects mice from high-fat diet induced obesity. Also it decreases blood glucose level, serum insulin level, and reduces lipid droplets accumulation. Altenusin inhibits trypanothione reductase from Trypanosoma cruzi.
potent and selective agonist of Farnesoid X receptor (FXR)
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SML2193-BULK:
SML2193-1MG:
SML2193-VAR:
最新バージョンのいずれかを選択してください：
試験成績書（COA）
Lot/Batch Number
Betania Barros Cota et al.
FEMS microbiology letters, 285(2), 177-182 (2008-06-19)
Parasitic protozoan species belonging to the genera Trypanosoma and Leishmania are the etiological agents of several diseases in tropical areas of the world, for which there is an urgent need for effective and affordable treatment. In this regard, we are
Sook Wern Chua et al.
ACS chemical neuroscience, 8(4), 743-751 (2017-01-10)
In Alzheimer's disease, the microtubule-associated protein tau forms intracellular neurofibrillary tangles (NFTs). A critical step in the formation of NFTs is the conversion of soluble tau into insoluble filaments. Accordingly, a current therapeutic strategy in clinical trials is aimed at
Christian M Garrido et al.
Scientific reports, 10(1), 9120-9120 (2020-06-06)
K-Ras must interact primarily with the plasma membrane (PM) for its biological activity. Therefore, disrupting K-Ras PM interaction is a tractable approach to block oncogenic K-Ras activity. Here, we found that avicin G, a family of natural plant-derived triterpenoid saponins
Zhihui Zheng et al.
Molecular pharmacology, 92(4), 425-436 (2017-07-26)
Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease. The incidence of NAFLD has increased steadily due to its close association with the global epidemic of obesity and type 2 diabetes. However, there is no effective pharmacological therapy
Jian Shi et al.
Cell reports, 33(1), 108225-108225 (2020-10-08)
Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines. Because prior work showed that the force of shear stress activates sphingomyelinase in endothelium, we considered if sphingomyelinase is relevant
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