SML3053

CC-3060

≥98% (HPLC)

• 別名: 4-[(2-Benzofuranylmethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, 4-[(Benzofuran-2-ylmethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
• 実験式（ヒル表記法）: C₂₂H₁₇N₃O₅
• CAS番号: 444288-86-2
• 分子量: 403.39
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCC4=CC5=C(C=CC=C5)O4)=CC=C3)=O)=O
• InChI: 1S/C22H17N3O5/c26-18-9-8-16(20(27)24-18)25-21(28)14-5-3-6-15(19(14)22(25)29)23-11-13-10-12-4-1-2-7-17(12)30-13/h1-7,10,16,23H,8-9,11H2,(H,24,26,27)
• InChI Key: GRICLJZNEMDVMA-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

CC-3060 is a cell-permeable pomalidomide analog that acts as a potent, efficacious and dose-dependent promoter of CRL4CRBN-mediated ZBTB16 (Promyelocytic Leukemia Zinc Finger protein or PLZF) proteasomal degradation (DC50 = 0.47 nM and a ymin of 28 in HT-1080 ZBTB16-ePL cells). CC-3060 is shown to directly interact with the C2H2 ZnF1 domain, form a ternary complex with CRBN/ZBTB16 and stimulate ZBTB16-RARα robust degradation (Ymin of 20 in RAR?-ZBTB16-ePL cells). Also facilitates degradation of CRBN neosubstrates IKZF1, ZFP91, and ZNF276 with no effect on GSPT1 and CSNK1A1.

cell-permeable pomalidomide analog that acts as a potent, efficacious and dose-dependent promoter of CRL4CRBN-mediated ZBTB16 proteasomal degradation

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable