384410

Chlorotrimethylsilane solution

1.0 M in THF

• 동의어(들): Trimethylchlorosilane
• Linear Formula: (CH₃)₃SiCl
• CAS Number: 75-77-4
• Molecular Weight: 108.64
• Beilstein: 1209232
• MDL number: MFCD00000502
• UNSPSC 코드: 12352302
• PubChem Substance ID: 24863995
• NACRES: NA.22

속성

• 양식: liquid
• Quality Level: 100
• 농도: 1.0 M in THF
• density: 0.88 g/mL at 25 °C
• SMILES string: C[Si](C)(C)Cl
• InChI: 1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
• InChI key: IJOOHPMOJXWVHK-UHFFFAOYSA-N

설명

일반 설명

Chlorotrimethylsilane (TMSCl) is a silylating agent employed in the silylation of alcohols, amines, carboxylic acids, thiols, and other functional groups. Silyl group serves as a protecting group for these original functional groups.

애플리케이션

Chlorotrimethylsilane (TMSCl) can be used as a reagent:

• To synthesize allenylsilane via carbolithiation of conjugated enynes with aryllithium.
• In the reductive coupling of aldehydes and ketones to produce corresponding 1,2 diols in the presence of zirconocene dichloride and magnesium.
• To prepare 4,4′-bis(trimethylsilyl)bicyclohexyl-2,2′-diene from 1,3-cyclohexadiene by reductive disilylation reaction.

안전성 정보

• 픽토그램: GHS02,GHS08,GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H225,H302,H314,H335,H351
• 예방조치 성명서: P201 - P210 - P233 - P261 - P280 - P370 + P378
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Flam. Liq. 2 - Skin Corr. 1A - STOT SE 3
• 표적 기관: Respiratory system
• 보충제 위험성: EUH014,EUH019
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point (°F): -4.0 °F - closed cup
• Flash Point (°C): -20 °C - closed cup
• 개인 보호 장비: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter