47625

Fmoc-Glu(OtBu)-OH

≥98.0% (HPLC), for peptide synthesis

• 동의어(들): Fmoc-L-glutamic acid 5-tert-butyl ester
• 실험식(Hill 표기법): C₂₄H₂₇NO₆
• CAS Number: 71989-18-9
• Molecular Weight: 425.47
• Beilstein: 3636375
• EC Number: 276-253-8
• MDL number: MFCD00037135
• UNSPSC 코드: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 57651045
• NACRES: NA.26

속성

• 제품명: Fmoc-Glu(OtBu)-OH, ≥98.0% (HPLC)
• 분석: ≥98.0% (HPLC)
• 양식: powder
• 광학 활성: [α]20/D −5.0±2.0°, c = 1% in acetic acid: water (4:1)
• 반응 적합성: reaction type: Fmoc solid-phase peptide synthesis
• 불순물: ~4% water
• 응용 분야: peptide synthesis
• 작용기: Fmoc
• 저장 온도: 2-8°C
• SMILES string: CC(C)(C)OC(=O)CC[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
• InChI: 1S/C24H27NO6/c1-24(2,3)31-21(26)13-12-20(22(27)28)25-23(29)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,27,28)/t20-/m0/s1
• InChI key: OTKXCALUHMPIGM-FQEVSTJZSA-N

설명

일반 설명

Fmoc-Glu(OtBu)-OH is widely used as a building block in peptide synthesis for the protection of amine groups.

애플리케이션

Fmoc-Glu(OtBu)-OH (Fmoc-L-glutamic acid 5-tert-butyl ester) can be employed as a:

• Ligand in the synthesis of cis-substituted cyclopropane carboxylic acids via C-H activation of cyclopropane carboxamides using Pd catalyst.
• Linker in the preparation of multi-small molecule-conjugated PTX (paclitaxel) derivatives.

It can be also used as a building block in the preparation of stapled α-helical peptides , and peptide C-terminal thioesters .

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)