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Merck
모든 사진(1)

주요 문서

47674

Sigma-Aldrich

Fmoc-Gln(Trt)-OH

≥98.0% (HPLC), for peptide synthesis

동의어(들):

Nα-Fmoc-Nδ-trityl-L-glutamine

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About This Item

실험식(Hill 표기법):
C39H34N2O5
CAS Number:
Molecular Weight:
610.70
Beilstein:
4343953
MDL number:
UNSPSC 코드:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

제품명

Fmoc-Gln(Trt)-OH, ≥98.0% (HPLC)

Quality Level

분석

≥98.0% (HPLC)

양식

powder

광학 활성

[α]/D -14.0±1.5°, c = 1% in DMF

반응 적합성

reaction type: Fmoc solid-phase peptide synthesis

응용 분야

peptide synthesis

작용기

Fmoc

저장 온도

2-8°C

SMILES string

OC(=O)[C@H](CCC(=O)NC(c1ccccc1)(c2ccccc2)c3ccccc3)NC(=O)OCC4c5ccccc5-c6ccccc46

InChI

1S/C39H34N2O5/c42-36(41-39(27-14-4-1-5-15-27,28-16-6-2-7-17-28)29-18-8-3-9-19-29)25-24-35(37(43)44)40-38(45)46-26-34-32-22-12-10-20-30(32)31-21-11-13-23-33(31)34/h1-23,34-35H,24-26H2,(H,40,45)(H,41,42)(H,43,44)/t35-/m0/s1

InChI key

WDGICUODAOGOMO-DHUJRADRSA-N

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일반 설명

Fmoc-Gln(Trt)-OH also known as Nα-Fmoc-Nδ-trityl-L-glutamine, a Fmoc protected amino acid derivative used as a reagent in the synthesis of peptides. As glutamine is protected with a trityl group, unwanted substitute products in the reactions can be prevented.

애플리케이션

Fmoc-Gln(Trt)-OH is used as a starting material in the Fmoc solid phase peptide synthesis of fellutamide B and N-octanoyl analog of fellutamide B.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

Protection of carboxamide functions by the trityl residue. Application to peptide synthesis
P Sieber, et.al.
Tetrahedron Letters, 32, 739-742 (1991)
Neurotrophic peptide aldehydes: Solid phase synthesis of fellutamide B and a simplified analog
JS Schneekloth
Bioorganic & Medicinal Chemistry Letters, 16, 3855-3858 (2006)
Cathleen Jendrny et al.
Chembiochem : a European journal of chemical biology, 17(8), 719-726 (2015-11-18)
Serpin proteins irreversibly inhibit serine proteases, but only a small part of the serpin reactive-center loop (RCL) is responsible for the initial protein-protein interaction (PPI). To develop peptidic protease inhibitors, kallikrein-related peptidases 7 (KLK7) and 5 (KLK5) were chosen. Firstly
Fatemeh Zabihi et al.
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Nanogels offer many unique features rendering them as very attractive candidates for drug delivery. However, for their applications the loading capacity and specific encapsulation, in particular for hydrophobic drugs, in a complex media are two critical factors. In this work
Marcus Pickhardt et al.
Current Alzheimer research, 14(7), 742-752 (2017-02-06)
Anti-aggregation drugs play an important role in therapeutic approaches for Alzheimer's disease. We have previously developed a number of compounds that are able to inhibit the pathological aggregation of Tau protein. One common obstacle to application is the limited penetration

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