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Merck
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주요 문서

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10107409001

Roche

Mitomycin C

crystalline powder, 98%, pkg of 2 mg

동의어(들):

Mitomycin C

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C15H18N4O5
CAS Number:
50-07-7
Molecular Weight:
334.33
UNSPSC 코드:
12352207

Quality Level

100

분석

98%

형태

crystalline powder

분자량

334.3

포장

pkg of 2 mg

제조업체/상표

Roche

항생제 활성 스펙트럼

Gram-negative bacteria
Gram-positive bacteria

동작 모드

DNA synthesis | interferes

저장 온도

2-8°C

InChI

1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1

InChI key

NWIBSHFKIJFRCO-WUDYKRTCSA-N

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관련 카테고리

일반 설명

Mitomycin C is an antitumor antibiotic.

애플리케이션

Mitomycin C has been used:
  • to cease mitosis
  • in phosphate buffer saline (PBS) for inactivation and plating mouse embryonic fibroblasts (MEFs)
  • as mutagen in mutagenicity assay

Mitomycin C is used as an inhibitor for studies of cell-free protein biosynthesis. It also inhibits DNA synthesis. It has been used as a genotoxic agent for tumor cells.

생화학적/생리학적 작용

Mitomycin C (MMC) acts as a prototype for drugs with bioreductive alkylation. It is mainly found to be active under anaerobic conditions. MMC exhibits a vast clinical antitumor spectrum effectively in gastric, pancreatic and breast cancer.

기타 정보

For life science research only. Not for use in diagnostic procedures.

픽토그램

Skull and crossbonesHealth hazard
GHS06,GHS08

신호어

Danger

유해 및 위험 성명서

H300,H351

Hazard Classifications

Acute Tox. 2 Oral - Carc. 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

does not flash

Flash Point (°C)

does not flash

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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이미 열람한 고객

Slide 1 of 2

1 of 2

Hydroxyurea Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.

Sigma-Aldrich

400046

Hydroxyurea

4-Nitroquinoline N-oxide ≥98%

Sigma-Aldrich

N8141

4-Nitroquinoline N-oxide

Preparation of mouse embryonic fibroblast cells suitable for culturing human embryonic and induced pluripotent stem cells
Jozefczuk J, et al.
Journal of Visualized Experiments, 130(64), e3854-e3854 (2012)
Renato B Baleeiro et al.
Oncoimmunology, 11(1), 2080329-2080329 (2022-06-04)
MHC class II expression is a hallmark of professional antigen-presenting cells and key to the induction of CD4+ T helper cells. We found that these molecules are ectopically expressed on tumor cells in a large proportion of patients with pancreatic
Jeremy Setton et al.
NPJ breast cancer, 7(1), 135-135 (2021-10-13)
Pathogenic germline mutations in the RAD51 paralog genes RAD51C and RAD51D, are known to confer susceptibility to ovarian and triple-negative breast cancer. Here, we investigated whether germline loss-of-function variants affecting another RAD51 paralog gene, RAD51B, are also associated with breast
Sertoli cell-mediated differentiation of bovine fetal mesenchymal stem cells into germ cell lineage using an in vitro co-culture system
Segunda MN, et al.
Theriogenology, 130, 8-18 (2019)
Natalia Garcia-Becerra et al.
Cancers, 15(2) (2023-01-22)
Cervical cancer (CC) is the fourth most common type of cancer among women; the main predisposing factor is persistent infection by high-risk human papillomavirus (hr-HPV), mainly the 16 or 18 genotypes. Both hr-HPVs are known to manipulate the cellular machinery
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Antibiotic Kill Curve

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