B6506

Benzamidine hydrochloride hydrate

≥99%

• 동의어(들): Amidinobenzene hydrochloride, Benzamidinium chloride, Benzenecarboximidamide hydrochloride
• Linear Formula: C₆H₅C(=NH)NH₂ · HCl · xH₂O
• CAS Number: 206752-36-5
• Molecular Weight: 156.61 (anhydrous basis)
• Beilstein: 3594959
• EC Number: 216-795-4
• MDL number: MFCD00066285
• UNSPSC 코드: 12352107
• PubChem Substance ID: 24278275
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 분석: ≥99%
• 형태: powder
• mp: 86-88 °C (lit.)
• solubility: water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• 저장 온도: 2-8°C
• SMILES string: Cl[H].[H]O[H].NC(=N)c1ccccc1
• InChI: 1S/C7H8N2.ClH.H2O/c8-7(9)6-4-2-1-3-5-6;;/h1-5H,(H3,8,9);1H;1H2
• InChI key: BQVJCMMLDJPBFZ-UHFFFAOYSA-N

설명

애플리케이션

Benzamidine hydrochloride hydrate has been used:

• in western blot analysis
• in immunoprecipitation
• in the purification of yeast dynein
• as a protease inhibitor in the preparation of brush-border membrane vesicles
• for the processing of human synovial fluid, blood and eye sleep
• to prevent non-specific degradation of cartilages

생화학적/생리학적 작용

Benzamidine HCl is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.

In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.

Peptidase inhibitor.

제조 메모

Benzamidine HCl is soluble in water and alcohol. Solubility testing in water at a concentration of 50 mg/ml yields a clear solution with heating. Benzamidine HCl is sensitive to oxidation. It is recommended to prepare solutions fresh each time in degassed water prior to use. However, frozen aliquots stored under inert gas, to exclude air, may be stable for a short time. Insufficient information is available to assess the shelf-life of a frozen solution.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves