55689

Alcohol Dehydrogenase equine

recombinant, expressed in E. coli, ≥0.5 U/mg

• 동의어(들): ADH
• CAS Number: 9031-72-5
• 효소 위원회 번호: 1.1.1.1 (BRENDA, IUBMB)
• EC Number: 232-870-4
• MDL number: MFCD00081305
• UNSPSC 코드: 12352204
• NACRES: NA.54

속성

• 생물학적 소스: equine
• Quality Level: 100
• 재조합: expressed in E. coli
• 설명: Isozyme E sequence
• 형태: lyophilized powder
• 특이 활성도: ≥0.5 U/mg
• 색상: white; light yellow
• pH: 7
• solubility: water: 5 mg/mL
• 응용 분야: life science and biopharma
• 저장 온도: −20°C
• 유전자 정보: equine ... ADH1(111772995)

설명

일반 설명

Research Area: Neuroscience
Alcohol dehydrogenase is a zinc metalloprotein that forms five classes of isoenzymes through the dimerization of eight different subunits.

애플리케이션

Alcohol Dehydrogenase equine has been used in in vitro alcohol dehydrogenase (Adh) assay.

생화학적/생리학적 작용

Alcohol dehydrogenase catalyzes the oxidative conversion of alcohol into aldehyde. It has a homodimeric structure with a co-enzyme binding domain at the C-terminal and an N-terminal catalytic domain. The active site is located at the interdomain cleft. Binding of NAD+ in the active site causes conformational changes which create the binding site for the alcohol substrate.

Horse liver alcohol dehydrogenase (HL-ADH) is an enzyme with broad specificity, capable of catalyzing the reversible oxidation of a wide variety of primary and secondary alcohols to form their corresponding aldehydes and ketones. Moreover, alcohol dehydrogenase can oxidize ethanol while simultaneously reducing nicotinamide adenine dinucleotide (NAD+) to NADH. Previous studies have demonstrated that ADH and ALDH variants can influence alcohol dependence. Additionally, the ADH genotype has been linked to lacunar infarction and neuropsychiatric diseases.

단위 정의

1 U corresponds to the amount of enzyme which reduces 1 μmol benzaldehyde per minute at pH 7.0 and 30 °C.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H334
• 예방조치 성명서: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable