A6706

O-Acetyl-L-carnitine hydrochloride

≥99% (titration)

• 동의어(들): Acetyl L-carnitine HCl, (R)-3-Acetoxy-4-(trimethylammonio)butyrate hydrochloride, ALC, ALCAR, R-(−)-2-Acetyloxy-3-carboxy-N,N,N-trimethyl-1-propanaminium chloride
• 실험식(Hill 표기법): C₉H₁₇NO₄ · HCl
• CAS Number: 5080-50-2
• Molecular Weight: 239.70
• Beilstein: 4340103
• MDL number: MFCD00082230
• UNSPSC 코드: 12352204
• PubChem Substance ID: 24891132
• NACRES: NA.83

속성

• 제품명: O-Acetyl-L-carnitine hydrochloride, ≥99% (titration), powder
• 생물학적 소스: synthetic
• Quality Level: 300
• 분석: ≥99% (titration)
• 양식: powder
• 광학 활성: [α]25/D −28°, c = 2 in H₂O(lit.)
• 색상: white to off-white
• mp: 194 °C
• solubility: H₂O: 100 mg/mL
• 응용 분야: cell analysis
• 저장 온도: 2-8°C
• SMILES string: C[N+](C)(C)C[C@H](OC(C)=O)CC(O)=O.[Cl-]
• InChI: 1S/C9H17NO4.ClH/c1-7(11)14-8(5-9(12)13)6-10(2,3)4;/h8H,5-6H2,1-4H3;1H/t8-;/m1./s1
• InChI key: JATPLOXBFFRHDN-DDWIOCJRSA-N

설명

일반 설명

Acetyl-L-carnitine (ALC/ALCAR), a quasi-vitamin is a metabolite of carnitine, present in mammalian plasma and tissues. It is the acetylated form of L-carnitine (LC). ALCAR is used as a dietary supplement. It is present at high level in the hypothalamus.

애플리케이션

O-Acetyl-L-carnitine hydrochloride has been used:

• as a bioactive compound to study its effect on the proliferation of B-lymphoblastoid cell lines (BLCL) and its immune modulating properties on influenza virus specific human B and T cell responses in vitro
• as in vitro maturation (IVM) media component to study its effects on lamb oocyte blastocyst rate, ultrastructure and mitochondrial DNA copy number
• as a metabolite/chemical standard to quantify the metabolite levels in murine tumor interstitial fluid

생화학적/생리학적 작용

Acetyl _L-carnitine (ALC) plays a vital role in intermediary metabolism and in improving female fertility. The oxidative and metabolic status of the female reproductive system is controlled by ALC. ALC possesses cholinomimetic and anti-inflammatory effects. It controls γ-amino butyric acid (GABA) system. ALC is capable of modifying the rate of glucose usage in the brain. It also possesses a neuroprotective role in the developing brain.

Endogenous mitochondrial metabolite that transports acetyl groups across the mitochondrial membrane. Exogenous acetylcarnitine enhances mitochondrial function in aged rats. As an acetate donor to coenzyme A, it increases the central and peripheral acetylcholine synthesis and function. Acetylcarnitine has antinociceptive activity that may be mediated by enhanced activity of muscarinic cholinergic receptors or mGlu2 glutamate receptors.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves