A9736
A-438079 hydrochloride hydrate
≥98% (HPLC)
동의어(들):
3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl pyridine hydrochloride hydrate
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C13H9Cl2N5·HCl · xH2O
CAS Number:
Molecular Weight:
342.61 (anhydrous basis)
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
형태
powder
저장 조건
desiccated
색상
white to beige
solubility
DMSO: 20 mg/mL, clear
주관자
Abbott
저장 온도
2-8°C
SMILES string
O.Cl.Clc1cccc(c1Cl)-c2nnnn2Cc3cccnc3
InChI
1S/C13H9Cl2N5.ClH.H2O/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9;;/h1-7H,8H2;1H;1H2
InChI key
ZHFJJBAKSROKNO-UHFFFAOYSA-N
애플리케이션
A-438079 hydrochloride hydrate has been used to determine its inhibitory effect on purinergic receptors. It has also been used to check its inhibitory effects on macrophages.
생화학적/생리학적 작용
A-438079 hydrochloride hydrate is a selective P2X7 purinoceptor antagonist in both human and rat with minimal activity at 75 different G-protein-coupled receptors, enzymes, transporters, and ion channels tested.
특징 및 장점
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Altered purinergic signaling in uridine adenosine tetraphosphate-induced coronary relaxation in swine with metabolic derangement
Zhou Z, et al.
Purinergic Signaling, 13(3), 319-329 (2017)
Resident macrophages cloak tissue microlesions to prevent neutrophil-driven inflammatory damage
Uderhardt S, et al.
Cell, 177(3), 541-555 (2019)
Kelaier Yang et al.
Frontiers in pharmacology, 11, 603689-603689 (2021-02-16)
Introduction: P2X7R excitation-interrelated NLRP3 inflammasome activation induced by high glucose contributes to the pathogenesis of diabetic retinopathy (DR). Relaxin-3 is a bioactive peptide with a structure similar to insulin, which has been reported to be effective in diabetic cardiomyopathy models
Haiyan Wang et al.
Journal of inflammation research, 13, 571-582 (2020-10-17)
Long-term use of morphine induces antinociceptive tolerance and limits its clinical efficacy. Neuroinflammation in the spinal cord is thought to play a pivotal role in the development of morphine tolerance. Toll-like receptor 4 (TLR4) and P2X7 receptor (P2X7R) are key
문서
We offer many products related to P2X ion channel family receptors for your research needs.
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