G5884

Guanosine 5′-triphosphate lithium salt

~95% (HPLC), powder

• 동의어(들): GTP lithium salt
• 실험식(Hill 표기법): C₁₀H₁₆N₅O₁₄P₃ · xLi⁺
• CAS Number: 85737-04-8
• Molecular Weight: 523.18 (free acid basis)
• MDL number: MFCD00070012
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24895236
• NACRES: NA.77

속성

• 분석: ~95% (HPLC)
• Quality Level: 200
• 형태: powder
• 색상: white
• solubility: H₂O: 100 mg/mL
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: [Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H16N5O14P3.Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
• InChI key: WDCLDKGIVWUKSE-GWTDSMLYSA-M

설명

애플리케이션

Guanosine 5′-triphosphate lithium salt has been used:

• In ribosome activity assay.
• In tubulin isolation and polymerization.
• In the determination of cell viability.

생화학적/생리학적 작용

GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

Guanosine 5′-triphosphate serves as a substrate for guanosine 5′-triphosphate 3′ diphosphate diphosphatase, a hydrolyzing enzyme and guanosine triphosphate guanyltransferase.

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

주의사항

Stability is much better than sodium salt.

제조 메모

Prepared by enzymatic phosphorylation of 5′-GMP.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves