I0523

IL-2 mouse

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• 동의어(들): Interleukin-2, T-cell growth factor, mIL-2, IL-2
• MDL number: MFCD00164816
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• 제품명: Interleukin-2 from mouse, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
• 생물학적 소스: mouse
• Quality Level: 200
• 재조합: expressed in E. coli
• 분석: ≥97% (SDS-PAGE)
• 양식: lyophilized powder
• 효능: ≤0.2 ng/mL ED₅₀
• 품질: endotoxin tested
• 분자량: 17.2 kDa
• 포장: pkg of 5X20 μg; pkg of 20 μg
• 기술: cell culture | mammalian: suitable
• 불순물: ≤1.000 EU/μg
• 색상: white
• UniProt 수납 번호: P04351
• 저장 온도: −20°C
• 유전자 정보: mouse ... Il2(16183)

설명

일반 설명

IL-2 (interleukin-2) codes for a pro-inflammatory cytokine. IL-2 is mostly expressed in T helper cells.

애플리케이션

Interleukin-2 from mouse has been used to induce sepsis in rat model. It has also been used in dendritic epidermal T cell culture.

생화학적/생리학적 작용

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long-term growth of activated T cells and related cell types. IL-2 plays a role in the activation and proliferation of natural killer cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor. IL-2 expression is known to reduce with age and results in influenza infection, neoplasms and lethal autoimmunity. IL-2 participates in T cell proliferation and differentiation and controls the homeostasis of T cell. As a part of immune response, IL-2 stimulates the action of T helper cell 1 and 2 along with endothelial white blood cells of skeletal muscles. IL-2 regulation is controlled by c-rel protein. IL-2 is a neurotrophic molecule and has special functions in cortical, hippocampal, septal, cerebellar and retinal neurons.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in 10 mM sodium citrate, pH 4.0.

분석 메모

Activity was determined by dose-dependent stimulation of murine CTLL-2 cells. ED₅₀ : ≤ 0.2 ng/ml (corresponds to a specific activity of 5 × 10⁶ units/mg)

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)