I2644

IL-2 human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• 동의어(들): IL-2, Interleukin-2, Interleukin-2 human, T-cell growth factor, hIL-2
• MDL number: MFCD00165721
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• 제품명: Interleukin-2 human, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
• 생물학적 소스: human
• Quality Level: 200
• 재조합: expressed in E. coli
• 양식: lyophilized powder
• 효능: ≤700 EC₅₀
• 품질: endotoxin tested
• 분자량: 15.5 kDa
• 포장: pkg of 5X10 μg; pkg of 10 μg
• 기술: cell culture | mammalian: suitable
• 불순물: ≤1 EU/μg
• UniProt 수납 번호: P60568
• 저장 온도: −20°C
• 유전자 정보: human ... IL2(3558)

설명

일반 설명

Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27. IL-2 is originally called as T cell growth factor.

애플리케이션

Interleukin-2 human has been used:

• in the stimulation of natural killer cells
• to study its ability to stimulate lymphocyte growth and prevent apoptosis
• as an antigen in enzyme-linked immunosorbent assay (ELISA), to analyse the human autoantibody reactivities in health and in type 1 diabetes mellitus

생화학적/생리학적 작용

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages. It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the essential functions of regulatory T cells. It is implicated in autoimmune disease. IL-2 is associated with apoptosis and thus, possesses antitumor response. It mediates CD41⁺ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation.

물리적 형태

Lyophilized, 0.2 μm filtered, no additives.

분석 메모

The biological activity is measured by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)