P0021

Pantoprazole sodium hydrate

≥98% (HPLC)

• 동의어(들): 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt hydrate, Pantozol hydrate, Protonix hydrate
• 실험식(Hill 표기법): C₁₆H₁₄F₂N₃O₄S · Na · xH₂O
• CAS Number: 718635-09-7
• Molecular Weight: 405.35 (anhydrous basis)
• UNSPSC 코드: 12352203
• PubChem Substance ID: 329819976
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 형태: powder
• 저장 조건: desiccated
• 기술: HPLC: suitable; gas chromatography (GC): suitable
• 색상: white to off-white
• solubility: H₂O: ≥20 mg/mL
• 주관자: Novartis
• 저장 온도: −20°C
• SMILES string: O.[Na+].COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[n-]2)c1OC
• InChI: 1S/C16H14F2N3O4S.Na.H2O/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;;/h3-7,15H,8H2,1-2H3;;1H2/q-1;+1;
• InChI key: CGJRLPRCWSHOFU-UHFFFAOYSA-N
• 유전자 정보: human ... ATP4A(495) , ATP4B(496)

설명

애플리케이션

Pantoprazole sodium hydrate has been used:

• as a standard in high-performance liquid chromatography (HPLC){58
• as a prazole to study its effects on prodrug activation and human immunodeficiency virus 1 (HIV-1) inhibition
• to study its effects on breast cancer resistance protein (BCRP) inhibitors in various in vitro membrane preparations from various cell lines

생화학적/생리학적 작용

Pantoprazole has the potential to treat symptoms of heartburn and acid regurgitation. It also has been studied to treat Helicobacter pylori infection and duodenal ulcer.

Pantoprazole is a benzimidazole derivative,activated in acidic environment. It is useful in treating long term prophylaxis and acid-related disorders.

Pantoprazole is a gastric proton pump inhibitor.

특징 및 장점

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable