S2671

Suramin sodium salt

≥98% (TLC)

• 동의어(들): Suramine sodium salt
• 실험식(Hill 표기법): C₅₁H₃₄N₆Na₆O₂₃S₆
• CAS Number: 129-46-4
• Molecular Weight: 1429.17
• Beilstein: 3694087
• EC Number: 204-949-3
• MDL number: MFCD00210217
• UNSPSC 코드: 12352201
• PubChem Substance ID: 24277738
• NACRES: NA.25

속성

• Quality Level: 200
• 분석: ≥98% (TLC)
• 양식: powder
• 불순물: <15% water (Karl Fischer)
• 색상: white to light brown
• solubility: H₂O: >10 mg/mL
• SMILES string: [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Cc1ccc(cc1NC(=O)c2cccc(NC(=O)Nc3cccc(c3)C(=O)Nc4cc(ccc4C)C(=O)Nc5ccc(c6cc(cc(c56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c2)C(=O)Nc7ccc(c8cc(cc(c78)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O
• InChI: 1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6
• InChI key: VAPNKLKDKUDFHK-UHFFFAOYSA-H
• 유전자 정보: human ... EGF(1950) , FGF1(2246) , P2RX1(5023) , P2RY1(5028) , PDGFA(5154) , PLD1(5337)

설명

일반 설명

Suramin is an antiparasitic drug, which blocks endothelial cell proliferation and increases tyrosine phosphorylation of many signalling proteins. It is associated with urticaria, paresthesias, vomiting and neurologic toxicity. Suramin is used to treat trypanosomiasis and onchocerciasis. It functions as an inhibitor of heparanase and also exhibits anti-AIDS (acquired immunodeficiency syndrome) property.

애플리케이션

Suramin sodium salt has been used:

• as a potent blocker of rat P2Y₂ purinergic receptor
• to study its effects on short circuit current (I_sc) across strial marginal cells
• to show its effects on initial burst of glial activity
• to assess its neuroprotective potential in rats
• as a purinoceptor inhibitor, to explore the mechanism of action of extracellular adenosine triphosphate (eATP)

생화학적/생리학적 작용

Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity.

기타 정보

To gain a comprehensive understanding of our extensive range of Oligosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)