SML0142

Valsartan

≥98% (HPLC)

• 동의어(들): N-(1-Oxopentyl)-N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine
• 실험식(Hill 표기법): C₂₄H₂₉N₅O₃
• CAS Number: 137862-53-4
• Molecular Weight: 435.52
• MDL number: MFCD00865840
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825190
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 형태: powder
• 광학 활성: [α]/D -55 to -70°, c = 1 in methanol
• 저장 조건: desiccated
• 색상: white to tan
• solubility: DMSO: ≥20 mg/mL
• 주관자: Novartis
• 저장 온도: 2-8°C
• SMILES string: CCCCC(=O)N(Cc1ccc(cc1)-c2ccccc2-c3nnn[nH]3)[C@@H](C(C)C)C(O)=O
• InChI: 1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1
• InChI key: ACWBQPMHZXGDFX-QFIPXVFZSA-N
• 유전자 정보: human ... AGTR1(185)

설명

애플리케이션

Mice were treated with valsartan to study the role of Ang II-dependent pathway in aldosterone-related effects.

생화학적/생리학적 작용

Valsartan is an Angiotensin II type 1 (AT1) receptor antagonist and anti-hypertensive. Valsartan renders protection against heart attack and stroke resulting from abrupt increase in blood pressure. Valsartan reduces myocardial-infarction-related complications in heart attack survivors.

특징 및 장점

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H336,H361d
• 예방조치 성명서: P201 - P308 + P313
• Hazard Classifications: Repr. 2 - STOT SE 3
• 표적 기관: Central nervous system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable