T3258

Tetracycline

98.0-102.0% (HPLC)

• 동의어(들): Tetracycline Hydrate
• 실험식(Hill 표기법): C₂₂H₂₄N₂O₈ · xH₂O
• CAS Number: 60-54-8
• Molecular Weight: 444.43 (anhydrous basis)
• Beilstein: 2230417
• EC Number: 200-481-9
• MDL number: MFCD00151232
• UNSPSC 코드: 51284017
• PubChem Substance ID: 24900120
• NACRES: NA.85

속성

• Quality Level: 200
• 분석: 98.0-102.0% (HPLC)
• 양식: powder or crystals
• 저장 조건: (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
• 색상: faint yellow to dark yellow
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria
• 동작 모드: protein synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
• InChI key: OFVLGDICTFRJMM-WESIUVDSSA-N
• 유전자 정보: human ... CYP1A2(1544) , TERT(7015)

설명

일반 설명

Chemical structure: tetracycline

생화학적/생리학적 작용

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

안전성 정보

• 픽토그램: GHS08,GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H302,H361fd,H411
• 예방조치 성명서: P202 - P264 - P270 - P273 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves