T3634

(+)-α-Tocopherol

from vegetable oil, Type V, ~1000 IU/g

• 동의어(들): 2,5,7,8-Tetramethyl-2-(4′,8′,12′-trimethyltridecyl)-6-chromanol, 5,7,8-Trimethyltocol, D-α-Tocopherol, Vitamin E
• 실험식(Hill 표기법): C₂₉H₅₀O₂
• CAS Number: 59-02-9
• Molecular Weight: 430.71
• Beilstein: 4712525
• EC Number: 200-412-2
• MDL number: MFCD00072045
• UNSPSC 코드: 12352205
• eCl@ss: 34058016
• PubChem Substance ID: 24900154
• NACRES: NA.79

속성

• 생물학적 소스: vegetable oil
• 유형: Type V
• 형태: viscous liquid
• 특이 활성도: ~1000 IU/g
• 색상: clear yellow to red
• refractive index: n20/D 1.505 (lit.)
• bp: 200-220 °C/0.1 mmHg (lit.)
• density: 0.95 g/mL at 25 °C (lit.)
• 저장 온도: −20°C
• SMILES string: CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1
• InChI: 1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
• InChI key: GVJHHUAWPYXKBD-IEOSBIPESA-N

설명

일반 설명

α-Tocopherol is synthesized from γ-tocopherol by the action of enzyme γ-tocopherol methyltransferase. It is the major form of Vitamin E in human plasma. It is present in sunflower seed oil.

애플리케이션

(+)-α-Tocopherol has been used:

• as a food supplement for juvenile cobia fish
• to evaluate its protective effect on bisphenol A induced oxidative stress in rats
• to test its chemopreventive efficacy in estrogen-mediated mammary cancer rats

생화학적/생리학적 작용

α-Tocopherol is essential for the photosynthesis in Synechocystis sp. strain PCC 6803. Supplementation with α-Tocopherol decreases lipid peroxidation and platelet aggregation. It inhibits protein kinase C and may play key role in gene regulation.

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.

포장

Packaged under argon in a sealed ampule.

기타 정보

Mixed constitutional (α, β, γ, δ) isomers.

품질

Approx. 670 mg D-α-tocopherol per gram. The non-α content is typically between 5-35 mg/g

주의사항

Subject to air oxidation.

물리적 특성

This product is miscible with chloroform or ethanol. It is practically insoluble in water but it is miscible with ether, acetone, and vegetable oils. It is unstable to alkaline conditions.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): 230.0 °F - closed cup
• Flash Point (°C): 110 °C - closed cup
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)