M22601

1-(2-Methoxyphenyl)piperazine

98%

• Synonym(s): 1-(2-Methoxyphenyl)piperazine, 1-(o-Anisyl)piperazine, 1-(o-Methoxyphenyl)piperazine, N-(2-Methoxyphenyl)piperazine, N-(o-Methoxyphenyl)piperazine, o-Methoxyphenylpiperazine
• Empirical Formula (Hill Notation): C₁₁H₁₆N₂O
• CAS Number: 35386-24-4
• Molecular Weight: 192.26
• Beilstein/REAXYS Number: 167888
• EC Number: 252-537-7
• MDL number: MFCD00005958
• UNSPSC Code: 12352100
• PubChem Substance ID: 24896714
• NACRES: NA.22

Properties

• assay: 98%
• refractive index: n20/D 1.575 (lit.)
• bp: 130-133 °C/0.1 mmHg (lit.)
• mp: 35-40 °C (lit.)
• density: 1.095 g/mL at 25 °C (lit.)
• SMILES string: COc1ccccc1N2CCNCC2
• InChI: 1S/C11H16N2O/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
• InChI key: VNZLQLYBRIOLFZ-UHFFFAOYSA-N
• Gene Information: mouse ... Htr3a(15561) ; rat ... Adra1a(29412) , Drd2(24318) , Htr1a(24473) , Htr2a(29595) , Htr7(65032)

Description

Application

1-(2-Methoxyphenyl)piperazine can be used:

• To functionalize pyrazolylvinyl ketones via Aza-Michael addition reaction.
• To prepare cyclic amine substituted Tröger′s base derivatives.
• To prepare functionalized bis(mercaptoimidazolyl)borates by reacting with the activated ester, [(1-methyl-2-mercaptoimidazol-5-yl)carbonyl]succinimide.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: 230.0 °F - closed cup
• flash_point_c: 110 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges