850365P

18:0 PC (DSPC)

Avanti Research^™ - A Croda Brand

• Synonym(s): 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine; DSPC; PC(18:0/18:0)
• Empirical Formula (Hill Notation): C₄₄H₈₈NO₈P
• CAS Number: 816-94-4
• Molecular Weight: 790.15
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• description: 1,2-distearoyl-sn-glycero-3-phosphocholine
• assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 g (850365P-1G); pkg of 1 × 200 mg (850365P-200MG); pkg of 1 × 25 mg (850365P-25MG); pkg of 1 × 500 mg (850365P-500MG)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• application(s): advanced drug delivery
• lipid type: phospholipids; cardiolipins
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O
• InChI: 1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1
• InChI key: NRJAVPSFFCBXDT-HUESYALOSA-N

Description

General description

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is a phospholtidylcholine with alkyl chain comprising 18 carbons. It has phophatidylcholine head group and its structure is similar to 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC).

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

18:0 PC (DSPC) has been used:

• in the microbubble monolayer preparation for biomolecule delivery studies into protoplasts
• in the preparation of liposomes for immobilization studies
• in the generation of porphyrin-phospholipid (PoP) liposomes for irinotecan (IRT) and doxorubicin delivery

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is used in combination with other members of phosphatidylcholine for the generation of mixed bilayer system. It is majorly used in conventional and stealth liposome preparation for drug delivery studies.

Packaging

20 mL Clear Glass Screw Cap Vial (850365P-1G)

20 mL Clear Glass Screw Cap Vial (850365P-500MG)

5 mL Amber Glass Screw Cap Vial (850365P-200MG)

5 mL Amber Glass Screw Cap Vial (850365P-25MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable