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07-1493

Sigma-Aldrich

Anti-Calcineurin Aβ Antibody

from rabbit, purified by affinity chromatography

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Synonym(s):
NFAT transcription complex cytosolic component, nuclear factor of activated T-cells, cytoplasmic,

calcineurin-dependent 1, nuclear factor of activated T-cells, cytosolic component 1
eCl@ss:
32160702

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

species reactivity (predicted by homology)

mammals (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PPP3CB(5532)

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This Item
07-149207-307HPA008789
vibrant-m

07-1493

Anti-Calcineurin Aβ Antibody

vibrant-m

07-1492

Anti-Calcineurin Aα Antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity purified immunoglobulin

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

NCBI accession no.

NP_000935.1

NCBI accession no.

NP_000935.1

NCBI accession no.

NP_009330

NCBI accession no.

-

Gene Information

human ... PPP3CB(5532)

Gene Information

human ... PPP3CA(5530)
mouse ... Ppp3Ca(19055)
rat ... Ppp3Ca(24674)

Gene Information

human ... STAT1(6772)

Gene Information

human ... NFATC2(4773)

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General description

Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal transduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin′s multifunctional capabilities in the regulation of calcium signaling. The Aα form of calcineurin is a major catalytic subunit gene isoform of calcineurin in most tissues that allows differentiation of Aα from the Aβ and Aγ isoforms.

Specificity

Recognizes the Aβ (polyproline) form of calcineurin, a less abundant gene isoform of calcineurin in most tissues. Allows differentiation of Aβ from the A α and A-γ isoforms. Reacts with calcineurin of all mammalian species.

Immunogen

KLH-conjugagted synthetic peptide corresponding to Calcineurin Aβ.

Application

Detect Calcineurin Aβ using this Anti-Calcineurin Aβ Antibody validated for use in WB, IH.
Research Category
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling

Quality

Evaluated by Western Blot in human brain lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected Calcineurin Aβ on 10 µg of human brain lysate.

Target description

Approx. 58 kDa

Linkage

Replaces: AB1697

Physical form

Affinity purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative.

Storage and Stability

Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will
remain unfrozen. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Analysis Note

Control
Human brain lysate

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Calcineurin regulates nuclear factor I dephosphorylation and activity in malignant glioma cell lines.
Brun, M; Glubrecht, DD; Baksh, S; Godbout, R
The Journal of Biological Chemistry null

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