1.07024

Chloroform

for analysis EMPARTA^® ACS

• Synonym(s): TCM, Trichloromethane, Methane trichloride, Methyl trichloride, Methylidyne trichloride, Trichloromethane
• Empirical Formula (Hill Notation): CHCl₃
• CAS Number: 67-66-3
• Molecular Weight: 119.38
• Beilstein/REAXYS Number: 1731042
• MDL number: MFCD00000826
• UNSPSC Code: 12191502
• EC Index Number: 200-663-8
• NACRES: NA.21

Properties

• grade: ACS reagent
• Quality Level: 200
• vapor density: 4.1 (vs air)
• vapor pressure: 160 mmHg ( 20 °C)
• product line: EMPARTA^®
• assay: ≥99.8% (according to ACS); 99.0-99.4% (GC)
• form: liquid
• potency: 695 mg/kg LD₅₀, oral (Rat); >3980 mg/kg LD₅₀, skin (Rabbit)
• impurities: ≤0.00003% Free chlorine; ≤0.001% Aldehydes and ketones (as C₃H₆O); ≤0.005% Carbonyl compounds (as CO); ≤0.01% Water
• evapn. residue: ≤0.001%
• color: clearAPHA: ≤10
• refractive index: n20/D 1.445 (lit.)
• bp: 60.5-61.5 °C (lit.)
• mp: −63 °C (lit.)
• density: 1.492 g/mL at 25 °C (lit.)
• cation traces: Pb: ≤0.000005%
• storage temp.: 2-30°C
• SMILES string: ClC(Cl)Cl
• InChI: 1S/CHCl3/c2-1(3)4/h1H
• InChI key: HEDRZPFGACZZDS-UHFFFAOYSA-N

Description

General description

EMD Millipore offers EMPARTA grade solvents for routine tasks in analytical laboratories. EMPARTA grade solvents offer fewer test parameters than EMSURE, yet are still of high quality. EMPARTA solvents meet ACS requirements, making them ideal for a wide range of analytical applications.

Application

• Novel Approaches for the Analysis and Isolation of Benzylisoquinoline Alkaloids in Chelidonium majus.: This study presents innovative techniques using chloroform for extracting and analyzing alkaloids, which could advance analytical methods in medicinal plant research (Ganzera et al., 2024).


• Preparation and optimization of dummy molecularly imprinted polymer-based solid-phase extraction system for selective enrichment of p-toluene sulfonate esters genotoxic impurities.: Focuses on a polymer-based extraction system using chloroform for purifying complex samples, enhancing the specificity and efficiency of contaminant detection in pharmaceuticals (Shan et al., 2024).


• Development of metabolome extraction strategy for metabolite profiling of skin tissue.: Discusses the development of a chloroform-based extraction protocol for comprehensive metabolite profiling, contributing to advancements in dermatological and cosmetic research (Kim et al., 2024).


• Sample Preparation from Plant Tissue for Gas Chromatography-Mass Spectrometry (GC-MS).: Details a method for preparing plant samples using chloroform for GC-MS analysis, aiming to improve the accuracy and reliability of phytochemical analyses (Kumar et al., 2024).


• Carotenoid Extraction from Plant Tissues.: Describes techniques for extracting carotenoids using chloroform, highlighting its efficiency and efficacy, which could be vital for research in plant biochemistry and nutritional science (Kumar et al., 2024).

Packaging

1.07024.2521: 2.5L, Minimum order quantity: 4

Analysis Note

Purity (GC): 99.0 - 99.4 %
Assay (according to ACS): ≥ 99.8 %
Identity (IR): conforms
Appearance: clear
Color: ≤ 10 Hazen
Acid and chloride: conforms
Free chlorine: ≤ 0.00003 %
Carbonyl compounds (as CO): ≤ 0.005 %
Readily carbonizable substances: conforms
Aldehydes and ketones (as C₃H₆O): ≤ 0.001 %
Suitability for determination with dithizone: conforms
Pb (Lead): ≤ 0.000005 %
Evaporation residue: ≤ 0.001 %
Water: ≤ 0.01 %
Stabilized with 0,6-1,0% Ethanol

Legal Information

EMPARTA is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H302,H315,H319,H331,H336,H351,H361d,H372
• pcodes: P202 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
• target_organs: Central nervous system, Liver,Kidney
• Storage Class: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: does not flash
• flash_point_c: does not flash