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AB1768-I

Sigma-Aldrich

Anti-GluR2 Antibody

from rabbit, purified by affinity chromatography

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Synonym(s):
Glutamate receptor 2, GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, rat, human

packaging

antibody small pack of 25 μg

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... GRIA2(2891)

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This Item
AB10529MABN103MAB397A4
Anti-GluR2 Antibody from rabbit, purified by affinity chromatography

AB1768-I

Anti-GluR2 Antibody

Anti-GluR-2 Antibody, CT serum, from rabbit

AB10529

Anti-GluR-2 Antibody, CT

biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

mouse

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

species reactivity

mouse, rat, human

species reactivity

mouse, rat

species reactivity

rat

species reactivity

mouse, rat

clone

polyclonal

clone

polyclonal

clone

022.19.5, monoclonal

clone

6C4, monoclonal

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General description

Glutamate receptors (GluRs) can be categorized as ionotropic or metabotropic and subcatergorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. In general, AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. Although subunit composition of AMPA receptors varies, they must contain at least one edited GluR2 subunit to be calcium impermeable. Relative calcium permeability in AMPA receptor channels may be significant in pathological neurotoxic damage and long term changes in nervous system responses.

Specificity

This antibody recognizes the cytoplasmic domain of Glutamate Receptor 2.

Immunogen

Epitope: Cytoplasmic domain
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of rat GluR2.

Application

Immunohistochemistry Analysis: A 1:4,000 dilution from a representative lot detected GluR2 in normal human and rat brain tissues.
Research Category
Neuroscience
Research Sub Category
Signaling Neuroscience
This GluR2 antibody is validated for use in WB & IHC for the detection of the GluR2 protein.

Quality

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected GluR2 in 10 µg of mouse brain tissue lysate.

Target description

~108 kDa observed. Three isoforms at 99 kDa, 99 kDa, and 100 kDa are known to exist due to alternative splicing.
There is no known homology to mouse and rat GluR1, GluR3 and GluR4. There was no homology detected to GluR1 and GluR3 in human, but there is 67% sequence homology to GluR4. An uncharacterized band may be observed at ~75 kDa in some cell lysates.

Linkage

Replaces: AB1768-25UG

Physical form

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Mouse brain tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Meenakshi M Asokan et al.
Nature communications, 9(1), 2468-2468 (2018-06-27)
Layer 5 (L5) cortical projection neurons innervate far-ranging brain areas to coordinate integrative sensory processing and adaptive behaviors. Here, we characterize a plasticity in L5 auditory cortex (ACtx) neurons that innervate the inferior colliculus (IC), thalamus, lateral amygdala and striatum.
Nikolaos Tzakis et al.
IBRO reports, 8, 91-100 (2020-04-18)
Preadolescent development is characterized by a reorganization of connectivity within and between brain regions that coincides with the emergence of complex behaviors. During the preadolescent period, the rodent hippocampus and regions of the frontal cortex are remodelled as the brain
Rifka C Derman et al.
Neuropharmacology, 131, 326-336 (2018-01-02)
Studies in humans suggest that stronger incentive motivational responses to Pavlovian food cues may drive over-consumption leading to and maintaining obesity, particularly in susceptible individuals. However, whether this enhanced incentive motivation emerges as a consequence of obesity or rather precedes
Yanaira Alonso-Caraballo et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 46(3), 569-578 (2020-07-31)
CP-AMPARs in the nucleus accumbens (NAc) mediate cue-triggered motivation for food and cocaine. In addition, increases in NAc CP-AMPAR expression and function can be induced by cocaine or sugary, fatty junk-foods. However, the precise nature of these alterations and the
Kaveri Arora et al.
PloS one, 12(5), e0177156-e0177156 (2017-05-26)
Vitamin B12 (cobalamin) deficiency is prevalent worldwide and causes megaloblastic anemia and neurologic deficits. While the anemia can be treated, the neurologic deficits can become refractive to treatment as the disease progresses. Therefore, timely intervention is critical for a favorable

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