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AB5302

Sigma-Aldrich

Anti-Amyloid Precursor Protein Antibody, KPI Domain

serum, Chemicon®

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Synonym(s):
APP
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

monkey, mouse, human, bovine

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... APP(351)

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AB5076

Anti-Amyloid Antibody, β 1-40/42

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

biological source

rabbit

biological source

rabbit

biological source

goat

biological source

rabbit

species reactivity

monkey, mouse, human, bovine

species reactivity

human, monkey

species reactivity

human

species reactivity

human, mouse

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

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Specificity

Amyloid Precursor Protein (APP), KPI Domain.

Immunogen

APP.

application

Anti-Amyloid Precursor Protein Antibody, KPI Domain is an antibody against Amyloid Precursor Protein for use in IP, WB, IC, IH.
Western blot: 1:250 - 1:1,000

Immunoprecipitation: Requires reductions and alkylation of disulfide bonds.

Immunocytochemistry: On Cos7 and NteraZ cell lines, requires reduction and alkylation of disulphide bonds.

Immunohistochemistry: Works on formaldehyde fixed, paraffin embedded tissue, requires reduction and alkylation of disulphide bonds or microwaving.

Optimal working dilutions must be determined by end user.

Reduction /Alkylation protocol:

To reduce incubate the slide (Blot) in TBS (PBS) + 50mM 2-mercaptoethanol at 37°C for 3 h in the dark. Wash twice with TBS, then incubate in TBS (PBS) + 20 mg/ ml of Iodoacetic acid for 30 min at room temperature. Wash twice with TBS (PBS), block and process as usual.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs.
Smith P, Al Hashimi A, Girard J, Delay C, Hebert SS.
Journal of Neurochemistry null
Jingdong Zhang et al.
Journal of neuroinflammation, 18(1), 100-100 (2021-04-28)
Microglia are resident innate immune cells in the brain, and activation of these myeloid cells results in secretion of a variety of pro-inflammatory molecules, leading to the development of neurodegenerative disorders. Lipopolysaccharide (LPS) is a widely used experimental stimulant in
Xinglong Yang et al.
Journal of biomedical research, 32(2), 136-144 (2018-01-24)
Microglia activation and white matter injury coexist after repeated episodes of mild brain trauma and ischemic stroke. Axon degeneration and demyelination can activate microglia; however, it is unclear whether early microglia activation can impair the function of white matter tracts
Victor O Oria et al.
Molecular oncology, 13(2), 456-479 (2018-12-18)
A disintegrin and a metalloprotease (ADAM)-9 is a metzincin cell-surface protease with strongly elevated expression in solid tumors, including pancreatic ductal adenocarcinoma (PDAC). In this study, we performed immunohistochemistry (IHC) of a tissue microarray (TMA) to examine the expression of ADAM9
Xinyan Huang et al.
The Journal of biological chemistry, 294(22), 8894-8906 (2019-04-24)
Early embryonic endocardium undergoes endothelial-to-mesenchymal transition to form cardiac cushion mesenchymal cells (MCs). Embryonic endocardium also gives rise to fibroblasts, intramyocardial adipocytes, and coronary mural cells, including smooth muscle cells and pericytes, in development. Whether endocardial cells directly differentiate into

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