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ABT330

Sigma-Aldrich

Anti-TSLP Antibody

from rabbit, purified by affinity chromatography

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Synonym(s):
TSLP Antibody, Thymic stromal lymphopoietin
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... TSLP(85480)

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This Item
ABF113PRS4021PRS4023
Anti-TSLP Antibody from rabbit, purified by affinity chromatography

ABT330

Anti-TSLP Antibody

Anti-TSLP Antibody from rabbit, purified by affinity chromatography

ABF113

Anti-TSLP Antibody

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

-

shipped in

wet ice

shipped in

wet ice

shipped in

dry ice

shipped in

dry ice

Gene Information

human ... TSLP(85480)

Gene Information

human ... TSLP(85480)

Gene Information

human ... TSLP(85480)

Gene Information

human ... TSLP(85480)

technique(s)

immunofluorescence: suitable, western blot: suitable, immunohistochemistry: suitable (paraffin)

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

technique(s)

immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

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General description

Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. TSLP is a four-helix-bundle cytokine that is expressed mainly by barrier epithelial cells and is a potent activator of several cell types such as myeloid dendritic cells. TSLP is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. TSLP is expressed in a number of tissues including heart, liver, and prostate.

Specificity

This antibody recognizes the intermediate domain of TSLP.

Immunogen

Epitope: Intermediate domain
KLH-conjugated linear peptide corresponding to the intermediate domain of human TSLP.

Application

Detect Thymic stromal lymphopoietin using this rabbit polyclonal antibody, Anti-TSLP Antibody validated for use in western blotting, IHC (Paraffin) & Immunofluorescence.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected TSLP in human prostate cancer and heart tissues.

Immunofluorescence Analysis: A 20 μg/mL from a representative lot detected TSLP in human brain cells.
Research Category
Cell Structure
Research Sub Category
Adhesion (CAMs)

Quality

Evaluated by Western Blotting in A20 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected TSLP in 15 µg of A20 cell lysate.

Target description

~23 kDa observed. The calculated molecular weight of this protein is 18 kDa, but can be observed at ~23 kDa due to high glycosylation.

Physical form

Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
A20 cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Kathleen M Buchheit et al.
The Journal of allergy and clinical immunology, 137(5), 1566-1576 (2015-12-23)
Prostaglandin (PG) D2 is the dominant COX product of mast cells and is an effector of aspirin-induced respiratory reactions in patients with aspirin-exacerbated respiratory disease (AERD). We evaluated the role of the innate cytokine thymic stromal lymphopoietin (TSLP) acting on
Simon G Royce et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(5), 6402-6411 (2019-02-16)
The airway remodeling (AWR) associated with chronic allergic airways disease (AAD)/asthma contributes to irreversible airway obstruction. This study compared and combined the antiremodeling and other effects of induced pluripotent stem cell and mesenchymoangioblast-derived mesenchymal stem cells (MCA-MSCs) with the corticosteroid
Simon G Royce et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(5), 6402-6411 (2019-02-16)
The airway remodeling (AWR) associated with chronic allergic airways disease (AAD)/asthma contributes to irreversible airway obstruction. This study compared and combined the antiremodeling and other effects of induced pluripotent stem cell and mesenchymoangioblast-derived mesenchymal stem cells (MCA-MSCs) with the corticosteroid
Amlan Chakraborty et al.
Biomaterials, 273, 120796-120796 (2021-04-25)
Asthma (chronic allergic airways disease, AAD) is characterized by airway inflammation (AI), airway remodeling (AWR) and airway hyperresponsiveness (AHR). Current treatments for AAD mainly focus on targeting AI and its contribution AHR, with the use of corticosteroids. However, there are
Eda Ustaoglu et al.
Indian journal of dermatology, 68(2), 170-177 (2023-06-05)
This study aims to investigate the anti-inflammatory effects of cinnamaldehyde in atopic dermatitis (AD) in the mouse model. Twenty-four mice were divided into four groups: Group A (control), group B [AD with no treatment (AD + NoTre)], group C [AD

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