Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

62929

Sigma-Aldrich

L-Lysine monohydrochloride

≥99.5% (AT), suitable for cell culture, BioUltra

Synonym(s):

(S)-2,6-Diaminohexanoic acid monohydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
H2N(CH2)4CH(NH2)CO2H·HCl
CAS Number:
657-27-2
Molecular Weight:
182.65
Beilstein/REAXYS Number:
3563889
EC Number:
211-519-9
MDL number:
MFCD00064564
UNSPSC Code:
12352209
PubChem Substance ID:
329759756
NACRES:
NA.26
Pricing and availability is not currently available.

Product Name

L-Lysine monohydrochloride, BioUltra, ≥99.5% (AT)

product line

BioUltra

Quality Level

200

assay

≥99.5% (AT)

form

powder or crystals

optical activity

[α]20/D +20.5±0.5°, c = 5% in 5 M HCl

technique(s)

cell culture | mammalian: suitable

impurities

insoluble matter, passes filter test
≤0.3% foreign amino acids

ign. residue

≤0.1% (as SO4)

loss

≤0.5% loss on drying, 20 °C (HV)

Looking for similar products? Visit Product Comparison Guide

General description

L-Lysine is an essential amino acid, not generated by the body, instead must be supplemented through food.[1]

Application

L-Lysine monohydrochloride has been used:
  • to study its effect on mRNA decay and destruction using mammalian cells[2]
  • to determine its effec on aTC1-6 cell proliferation[3]
  • to study the dynamics of the phosphoproteome upon amino acid supplement removal in the growth medium[4]

Biochem/physiol Actions

L-Lysine is associated with a number of biochemical reactions such as acetylation, O-linked glycosylation, ubiquitination and protein methylation. Lysine participates in the regulation of NO (nitric oxide) synthesis. It possesses antiviral activity, therefore it is used in the treatment of Herpes simplex.[1] L-Lysine is believed to prevent osteoporosis of bones, which is a characteristic of vascular calcification.[5] Glutaric aciduria type I and pyridoxine-dependent epilepsy occurs due to lack of L-lysine catabolic pathway.[6] Hydroxylysine is a component of collagen[1]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCM7412
BCCL5404
BCCJ9746
BCCH3276
BCCG2963

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Characterization of early autophagy signaling by quantitative phosphoproteomics
Rigbolt KTG, et al.
Autophagy, 10(2), 356-371 (2014)
ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation
Sundaramoorthy E, et al.
Molecular Cell, 65(4), 751-760 (2017)
Amino acid transporter Slc38a5 controls glucagon receptor inhibition-induced pancreatic alpha cell hyperplasia in mice
Kim J, et al.
Cell Metabolism, 25(6), 1348-1361 (2017)
Understanding cerebral L-lysine metabolism: the role of L-pipecolate metabolism in Gcdh-deficient mice as a model for glutaric aciduria type I.
Posset R
Journal of inherited metabolic disease, 38(2), 265-272 (2015)
Dietary l-Lysine Prevents Arterial Calcification in Adenine-Induced Uremic Rats
Akihiro Shimomura
Journal of the American Society of Nephrology, 25(9), 1954-1965 (2014)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service