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P4722

Sigma-Aldrich

Pyridoxine hydrochloride

meets USP testing specifications

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Synonym(s):
Adermine hydrochloride, PN HCl, Pyridoxol hydrochloride, Vitamin B6 hydrochloride
Empirical Formula (Hill Notation):
C8H11NO3 · HCl
CAS Number:
Molecular Weight:
205.64
Beilstein:
3632435
EC Number:
MDL number:
eCl@ss:
34058008
PubChem Substance ID:
NACRES:
NA.21

biological source

synthetic (organic)

Quality Level

Agency

USP/NF
meets USP testing specifications

Assay

98.0-102.0% dry basis

form

powder

color

white

mp

214-215 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

Cl[H].Cc1ncc(CO)c(CO)c1O

InChI

1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H

InChI key

ZUFQODAHGAHPFQ-UHFFFAOYSA-N

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This Item
P6280P9755PHR1036
Pyridoxine hydrochloride meets USP testing specifications

Sigma-Aldrich

P4722

Pyridoxine hydrochloride

-
Pyridoxine hydrochloride BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

Sigma-Aldrich

P6280

Pyridoxine hydrochloride

Essential+ Grade
Pyridoxine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

P9755

Pyridoxine hydrochloride

-
Pyridoxine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1036

Pyridoxine hydrochloride

-
assay

98.0-102.0% dry basis

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

form

powder

form

powder

form

powder

form

-

color

white

color

white to off-white

color

white to off-white

color

-

mp

214-215 °C (lit.)

mp

214-215 °C (lit.)

mp

214-215 °C (lit.)

mp

214-215 °C (lit.)

application(s)

pharmaceutical (small molecule)

application(s)

agriculture

application(s)

-

application(s)

pharmaceutical (small molecule)

General description

Vitamin B group is water-soluble and exists in six forms namely the pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phosphate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. The food sources of vitamin B6 include grains, nuts, fruits, vegetables and meat.

Application

Pyridoxine hydrochloride has been used to test its neuroprotective functionality in traumatic brain injury (TBI) rats. It has also been used as a reference standard to quantify vitamin B6 in feed and digesta samples using high-performance liquid chromatography(HPLC).

Biochem/physiol Actions

Pyridoxine plays a key role in metabolism both carbohydrates and amino acids. It supports brain development and its deficiency levels may lead to depletion of γ-aminobutyric acid (GABA) levels. Pyridoxine catalyzes the neurotransmitter biosynthesis like dopamine and serotonin. Pyridoxine in excess or deficient may lead to neuropathy.

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin
Calderon-Ospina CA, et al.
CNS Neuroscience & Therapeutics (2019)
Pyridoxine administration improves behavioral and anatomical outcome after unilateral contusion injury in the rat
Kuypers NJ and Hoane MR
Journal of Neurotrauma, 27(7), 1275-1282 (2010)
Nutritional neuropathies
Hammond N, et al.
Neurologic Clinics, 31(2), 477-477 (2013)
Effects of forage family on apparent ruminal synthesis of B vitamins in lactating dairy cows
Castagnino DS, et al.
Journal of Dairy Science, 99(3), 1884-1894 (2016)
Determination of vitamin B6 (pyridoxine) in pharmaceutical preparations by cyclic voltammetry at a copper (II) hexacyanoferrate (III) modified carbon paste electrode
Teixeira MFS, et al.
Journal of the Brazilian Chemical Society, 14(2), 316-321 (2003)

Articles

This page segues to comprehensive insights on how Vitamin B6, Pyridoxal and Pyridoxine affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies. The page introduces the in vitro chemistry and biochemistry of pyridoxal, pyridoxine.

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