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Y0000517

Glutathione

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
L-Glutathione reduced, γ-L-Glutamyl-L-cysteinyl-glycine, GSH
Linear Formula:
H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
CAS Number:
Molecular Weight:
307.32
Beilstein:
1729812
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

glutathione

manufacturer/tradename

EDQM

mp

192-195 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O

InChI

1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

InChI key

RWSXRVCMGQZWBV-WDSKDSINSA-N

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This Item
1294820PHR1359G4251
Glutathione European Pharmacopoeia (EP) Reference Standard

Y0000517

Glutathione

Glutathione United States Pharmacopeia (USP) Reference Standard

USP

1294820

Glutathione

Glutathione Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1359

Glutathione

L-Glutathione reduced ≥98.0%

Sigma-Aldrich

G4251

L-Glutathione reduced

manufacturer/tradename

EDQM

manufacturer/tradename

USP

manufacturer/tradename

-

manufacturer/tradename

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

detection

format

neat

format

neat

format

neat

format

-

API family

glutathione

API family

glutathione

API family

glutathione

API family

-

mp

192-195 °C (dec.) (lit.)

mp

192-195 °C (dec.) (lit.)

mp

192-195 °C (dec.) (lit.)

mp

192-195 °C (dec.) (lit.)

Amino Acid Sequence

γ-Glu-Cys-Gly

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

Biochem/physiol Actions

Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

EP issued certificate and SDS can be found here.
Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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