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53319

Sigma-Aldrich

L-Histidine

BioUltra, ≥99.5% (NT)

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Synonym(s):
(S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773
Empirical Formula (Hill Notation):
C6H9N3O2
CAS Number:
Molecular Weight:
155.15
Beilstein:
84088
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:

product line

BioUltra

Quality Level

Assay

≥99.5% (NT)

form

powder or crystals

optical activity

[α]20/D −39±1°, c = 2% in H2O

impurities

insoluble matter, passes filter test
≤0.5% foreign amino acids

ign. residue

≤0.1% (as SO4)

loss

≤0.5% loss on drying, 110 °C

color

white

pH

7.0-8.0 (25 °C, 0.1 M in H2O)

mp

282 °C (dec.) (lit.)
~285 °C (dec.)

solubility

H2O: 0.1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤100 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
NH4+: ≤500 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

0.1 M in H2O

UV absorption

λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05

SMILES string

N[C@@H](Cc1c[nH]cn1)C(O)=O

application(s)

detection

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

InChI key

HNDVDQJCIGZPNO-YFKPBYRVSA-N

Gene Information

human ... CA1(759) , CA2(760)

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This Item
H8000H6034H3911
L-Histidine BioUltra, ≥99.5% (NT)

Sigma-Aldrich

53319

L-Histidine

Premium Grade
L-Histidine ReagentPlus®, ≥99% (TLC)

Sigma-Aldrich

H8000

L-Histidine

-
L-Histidine suitable for cell culture, meets EP, USP testing specifications, from non-animal source

Sigma-Aldrich

H6034

L-Histidine

-
L-Histidine

SAFC

H3911

L-Histidine

-
assay

≥99.5% (NT)

assay

≥99% (TLC)

assay

98.5-101.0%

assay

≥98.5%

form

powder or crystals

form

powder

form

powder

form

crystalline powder

optical activity

[α]20/D −39±1°, c = 2% in H2O

optical activity

-

optical activity

[α]20/D 12.0 to 12.8 °, c = 11 in 6 M HCl, [α]25/D 12.6 to 14.0 °, c = 11 in 6 M HCl

optical activity

-

impurities

insoluble matter, passes filter test, ≤0.5% foreign amino acids

impurities

-

impurities

endotoxin, tested

impurities

endotoxin, heavy metals, trace metals, residual solvents, tested

color

white

color

white to off-white

color

white to off-white

color

-

Application

L-Histidine has been used for characterization of ZnO nanorod in an attempt to develop a technique for the ultra-low level detection of l-histidine.

Biochem/physiol Actions

Precursor of histamine by action of histidine decarboxylase.
L-Histidine is involved in the one-carbon unit metabolism. It is associated with protein methylation. L-Histidine is a part of hemoglobin structure and function. L-Histidine is a component of dipeptides with antioxidative property. Histidine serves as a precursor for the formation of histamine, which is associated with allergic responses. Urocanic acid, an immune response modulator in skin is also biosynthesised from histidine.

Other Notes

Amino acid spacing in isotachophoresis on polyacrylamide gels - a critical evaluation; Prevents circular DNA strand cleavage in a xanthine-xanthine oxidase system; Growth requirement of various microorganisms.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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