H6034

L-Histidine

98.5-101.0%, suitable for cell culture, non-animal source, meets EP, USP testing specifications

• Synonym(s): (S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773
• Empirical Formula (Hill Notation): C₆H₉N₃O₂
• CAS Number: 71-00-1
• Molecular Weight: 155.15
• Beilstein/REAXYS Number: 84088
• EC Number: 200-745-3
• MDL number: MFCD00064315
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24895728
• NACRES: NA.26

Properties

• product name: L-Histidine, suitable for cell culture, meets EP, USP testing specifications, from non-animal source
• biological source: non-animal source
• agency: meets EP testing specifications; meets USP testing specifications
• assay: 98.5-101.0%
• form: powder
• optical activity: [α]20/D 12.0 to 12.8 °, c = 11 in 6 M HCl; [α]25/D 12.6 to 14.0 °, c = 11 in 6 M HCl
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, tested
• color: white to off-white
• mp: 282 °C (dec.) (lit.)
• solubility: H₂O: 50 mg/mL
• cation traces: As: ≤1 ppm; Fe: ≤10 ppm; NH₄⁺: <0.02%
• application(s): peptide synthesis; pharmaceutical (small molecule)
• functional group: (Imidazole); amine; carboxylic acid
• storage temp.: room temp
• SMILES string: N[C@@H](Cc1c[nH]cn1)C(O)=O
• InChI: 1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
• InChI key: HNDVDQJCIGZPNO-YFKPBYRVSA-N
• Gene Information: human ... CA1(759) , CA2(760)

Description

General description

L-Histidine is a proteinogenic amino acid and an essential amino acid required for histamine production. This positively charged amino acid is vital for growth, tissue repair, myelin sheath maintenance, and histamine synthesis. Histamine plays critical roles in immunity, gastric secretion, and more. L-Histidine is essential for blood cell production and tissue protection against radiation and heavy metals. L-Histidine plays a role as a metabolite and also acts as a cofactor in enzyme protection during protein synthesis. It is an L-enantiomer of histidine and is necessary for histamine synthesis and human development. L-Histidine finds applications in cell culture, metabolomics and biochemical research.

Application

L-histidine has been used as a component in agar plates containing 5-fluorocytosine (5-FC) for the selection of yeast transformants. It has also been used as a component of adult mouse keratinocyte growth medium.

Biochem/physiol Actions

L-Histidine is an essential amino acid that binds to metal ions and may aid in the transport of copper. Histidine is widely present at the active sites of enzymes. It also has a role in binding of heme groups, macromolecules and phosphate groups in the binding sites of proteins.

Precursor of histamine by action of histidine decarboxylase.

Features and Benefits

• Can be used in Metabolomics and Biochemical research
• High-quality compound suitable for multiple research applications

Other Notes

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Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)