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H5659

Sigma-Aldrich

L-Histidine monohydrochloride monohydrate

from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%

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Synonym(s):
L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride
Empirical Formula (Hill Notation):
C6H9N3O2 · HCl · H2O
CAS Number:
5934-29-2
Molecular Weight:
209.63
Beilstein:
4168261
MDL number:
MFCD00151027
eCl@ss:
32160406
PubChem Substance ID:
24895703
NACRES:
NA.26

biological source

non-animal source

Quality Level

300

Agency

meets EP testing specifications

product line

BioXtra

Assay

98.5-101.0%

form

crystalline powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

254 °C (dec.) (lit.)

solubility

H2O: 100 mg/mL

SMILES string

O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1

InChI key

CMXXUDSWGMGYLZ-XRIGFGBMSA-N

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1 of 4

This Item
H40368.16005H6034
L-Histidine monohydrochloride monohydrate from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%

Sigma-Aldrich

H5659

L-Histidine monohydrochloride monohydrate

L-Histidine monohydrochloride monohydrate

SAFC

H4036

L-Histidine monohydrochloride monohydrate

(S)-(+)-Histidine hydrochloride monohydrate for synthesis

Sigma-Aldrich

8.16005

(S)-(+)-Histidine hydrochloride monohydrate

L-Histidine suitable for cell culture, meets EP, USP testing specifications, from non-animal source

Sigma-Aldrich

H6034

L-Histidine

assay

98.5-101.0%

assay

≥98.5%

assay

-

assay

98.5-101.0%

form

crystalline powder

form

powder

form

crystals

form

powder

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

impurities

endotoxin, heavy metals, residual solvents, tested

impurities

-

impurities

endotoxin, tested

color

white

color

-

color

-

color

white to off-white

Application

L-Histidine monohydrochloride monohydrate has been used in bee cell culture medium.
L-Histidine monohydrochloride, non-animal, is used in cell culture media formulations used in biomanufacturing. The use of non-animal-sourced L-Histidine and other components avoids the risk of contaminating bioproducts with adventitious viruses.

Biochem/physiol Actions

L-Histidine is involved in the one-carbon unit metabolism. It is associated with protein methylation. L-Histidine is a part of hemoglobin structure and function. L-Histidine is a component of dipeptides with antioxidative property. Histidine serves as a precursor for the formation of histamine, which is associated with allergic responses. Urocanic acid, an immune response modulator in skin is also biosynthesised from histidine.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Medium for development of bee cell cultures (Apis mellifera: Hymenoptera: Apidae).
Hunter WB
In Vitro Cellular & Developmental Biology. Animal, 46(2), 83-86 (2010)
Yoshihiro Kaneko et al.
Journal of bioscience and bioengineering, 109(3), 274-280 (2010-02-18)
Pharmaceutical manufacturing plants can be operated continuously for several months. It is therefore important to use cells with long-term stability for the production of active ingredients. We investigated the reliability and long-term stability of an antibody-producing cell line. A recombinant
Jean-Christophe Drugmand et al.
Biotechnology advances, 30(5), 1140-1157 (2011-10-11)
Insect cells (IC) and particularly lepidopteran cells are an attractive alternative to mammalian cells for biomanufacturing. Insect cell culture, coupled with the lytic expression capacity of baculovirus expression vector systems (BEVS), constitutes a powerful platform, IC-BEVS, for the abundant and
D J Williams et al.
IEE proceedings. Nanobiotechnology, 152(6), 207-210 (2006-01-31)
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A precise understanding of processes managing heterologous protein production in vitro and in vivo is essential for the manufacture of sophisticated biopharmaceuticals as well as for future gene therapy and tissue engineering initiatives. Capitalizing on the gravity-enforced self-assembly of monodispersed
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