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57858

Sigma-Aldrich

Sodium iodoacetate

BioUltra, ≥99.5% (NT)

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Synonym(s):
Iodoacetic acid sodium salt
Linear Formula:
ICH2COONa
CAS Number:
Molecular Weight:
207.93
Beilstein:
4009322
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.26

product line

BioUltra

Quality Level

Assay

≥99.5% (NT)

impurities

insoluble matter, passes filter test
≤0.5% water

mp

208 °C (dec.) (lit.)

solubility

methanol: 0.1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤100 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤500 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

absorption

cut-off at 335 nm in methanol at 0.1 M

storage temp.

−20°C

SMILES string

[Na+].[O-]C(=O)CI

InChI

1S/C2H3IO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1

InChI key

AGDSCTQQXMDDCV-UHFFFAOYSA-M

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1 of 4

This Item
I2512I914871183
Sodium iodoacetate BioUltra, ≥99.5% (NT)

Sigma-Aldrich

57858

Sodium iodoacetate

Premium Grade
Sodium iodoacetate ≥98%

Sigma-Aldrich

I2512

Sodium iodoacetate

-
Sodium iodoacetate ≥98%, BioUltra

Sigma-Aldrich

I9148

Sodium iodoacetate

-
Sodium acetate anhydrous, BioUltra, for luminescence, for molecular biology, ≥99.0% (NT)

Sigma-Aldrich

71183

Sodium acetate

Premium Grade
mp

208 °C (dec.) (lit.)

mp

208 °C (dec.) (lit.)

mp

208 °C (dec.) (lit.)

mp

>300 °C (dec.) (lit.)

solubility

methanol: 0.1 M at 20 °C, clear, colorless

solubility

H2O: 100 mg/mL

solubility

H2O: 0.5 M, clear, colorless

solubility

H2O: 3 M at 20 °C, clear, colorless

cation traces

Al: ≤5 mg/kg, As: ≤0.1 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤500 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg

cation traces

-

cation traces

Al: ≤0.0005%, Ca: ≤0.001%, Cu: ≤0.001%, Fe: ≤0.0005%, K: ≤0.02%, Mg: ≤0.0005%, NH4+: ≤0.05%, Pb: ≤0.001%, Zn: ≤0.0005%

cation traces

Al: ≤5 mg/kg, As: ≤0.1 mg/kg, Ba: ≤10 mg/kg, Bi: ≤5 mg/kg, Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤200 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤10 mg/kg, Zn: ≤5 mg/kg

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

Application

Reagent for the modification of cysteine residues in proteins. Used in protein sequencing (including by Sanger in sequencing bovine insulin) to prevent oxidation of -SH sidechains.
Reagent for the modification of cysteine residues in proteins. Used to induce animal osteoarthritis model system, which mimics both symptoms and histopathology of the human disease.

Other Notes

Sulfhydryl reagent

Pictograms

CorrosionSkull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

406.4 °F

Flash Point(C)

208 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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J L Leonard et al.
Biochimica et biophysica acta, 787(2), 122-130 (1984-06-14)
Pretreatment of renal iodothyronine 5'-deiodinase with sulfhydryl reagents, iodoacetate, iodoacetamide and N-alkylmaleimides, results in irreversible loss of catalytic activity. Iodoacetate and iodoacetamide were the most potent inhibitors, being 100- to 1000-times more potent than N-alkylmaleimides. Iodoacetate and iodoacetamide inactivation followed
F.R. Gurd
Methods in Enzymology, 11, 532-532 (1973)
Mohammed Gagaoua et al.
Journal of agricultural and food chemistry, 63(30), 6799-6809 (2015-07-15)
Many studies on color biochemistry and protein biomarkers were undertaken in post-mortem beef muscles after ≥24 hours. The present study was conducted on Longissimus thoracis muscles of 21 Blond d'Aquitaine young bulls to evaluate the relationships between protein biomarkers present
Joon Shik Yoon et al.
American journal of physical medicine & rehabilitation, 94(8), 644-648 (2014-11-22)
The aim of this study was to investigate the potential of using phase-contrast radiography to detect early changes in articular cartilage in a mouse model of osteoarthritis. An iodoacetate-induced mouse model of osteoarthritis was used. Mice with iodoacetate-induced osteoarthritis were
K Nakyinsige et al.
Meat science, 98(4), 701-708 (2014-08-05)
This study assessed the effect of gas stunning which has not been conducted until now in comparison with slaughter without stunning on the welfare and meat quality of rabbits. Eighty male New Zealand White rabbits were divided into two groups

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