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P2443

Sigma-Aldrich

Pluronic® F-127

powder, BioReagent, suitable for cell culture

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Synonym(s):
Non-ionic copolymer surfactant
Linear Formula:
(C3H6O·C2H4O)x
CAS Number:
9003-11-6
MDL number:
MFCD00082049
PubChem Substance ID:
24897874
NACRES:
NA.75

description

Non-ionic
contains 100ppm BHT

Quality Level

200

product line

BioReagent

form

powder

mol wt

~12600 g/mol

technique(s)

cell culture | mammalian: suitable

CMC

950-1000 ppm (~25°C)

transition temp

cloud point >100 °C

HLB

18 - 23

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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Pluronic® F-127 powder, BioReagent, suitable for cell culture

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Neurturin human

product line

BioReagent

product line

BioReagent

product line

BioReagent

product line

-

form

powder

form

-

form

lyophilized powder

form

lyophilized

mol wt

~12600 g/mol

mol wt

average mol wt 8350

mol wt

-

mol wt

11.8 kDa

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | insect: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

CMC

950-1000 ppm (~25°C)

CMC

0.04 mM

CMC

-

CMC

-

General description

Pluronicpluronic® F-127, also known as poloxamer 407, is a non-toxic and nonionic copolymer. It contains polyethylene oxide-polypropylene oxide arranged in a triblock structure to form PEO-PPO-PEO symmetric. Surfactant properties of this polymer derived from its amphiphilic nature, allow them to interact with hydrophobic surfaces and biological membranes.

Application

Pluronic® F-127 has been used:

  • as a delivery system for a peptide to the wound site to study the effect of the peptide on wound healing in mice.
  • as a surface coating for PDMS (polydimethylsiloxane) stamps to make them hydrogel repellent.
  • in the preparation of calcium indicator stock solution for measuring neural activities.
  • as a component of phosphate-buffered saline (PBS), to lower unspecific cell and protein adhesion to a PDMS-based microfluidic device.
  • This non-ionic copolymer surfactant is suitable for use in insect cell culture applications as an antifoaming agent.

Biochem/physiol Actions

Pluronic® F-127 is a thermo-reversible gel that finds its application in different industries due to its high thermosensitivity, biodegradability, and biocompatibility properties. These properties make this polymer suitable for use as a versatile drug carrier.Pluronic® F-127 improves the therapeutic efficiency of drugs by increasing their bioavailability and thermostability. Additionally, it can promote cellular attachment and collagen formation, which facilitates angiogenesis and tissue regeneration. Due to its efficacy, Pluronic F-127 has been utilized in the encapsulation of mesenchymal stem cells (MSCs) to aid in the regeneration of tissues with low levels of vascularity, such as epithelial tissues, adipose tissues, cartilage, tendons, and bone tissues.

Legal Information

Pluronic is a registered trademark of BASF

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Pablo Martinez et al.
The Journal of cell biology, 219(8) (2020-06-23)
The microtubule cytoskeleton serves as a dynamic structural framework for mitosis in eukaryotic cells. TANGLED1 (TAN1) is a microtubule-binding protein that localizes to the division site and mitotic microtubules and plays a critical role in division plane orientation in plants.
Federico Ceriani et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(46), E7194-E7201 (2016-11-04)
Spatially and temporally coordinated variations of the cytosolic free calcium concentration ([Ca2+]c) play a crucial role in a variety of tissues. In the developing sensory epithelium of the mammalian cochlea, elevation of extracellular adenosine trisphosphate concentration ([ATP]e) triggers [Ca2+]c oscillations
Philippe Marmottant et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(41), 17271-17275 (2009-10-07)
Cell aggregates are a tool for in vitro studies of morphogenesis, cancer invasion, and tissue engineering. They respond to mechanical forces as a complex rather than simple liquid. To change an aggregate's shape, cells have to overcome energy barriers. If
Annemarie Lüdecke et al.
Nature communications, 9(1), 2214-2214 (2018-06-09)
Form and function of the mitotic spindle depend on motor proteins that crosslink microtubules and move them relative to each other. Among these are kinesin-14s, such as Ncd, which interact with one microtubule via their non-processive motor domains and with
Bana Shriky et al.
Journal of colloid and interface science, 565, 119-130 (2020-01-17)
Understanding structure-property relationships is critical for the development of new drug delivery systems. This study investigates the properties of Pluronic smart hydrogel formulations for future use as injectable controlled drug carriers. The smart hydrogels promise to enhance patient compliance, decrease
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