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A0310

Sigma-Aldrich

Monoclonal Anti-GABA antibody produced in mouse

clone GB-69, ascites fluid

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Synonym(s):
GABA Antibody - Monoclonal Anti-GABA antibody produced in mouse, Gaba Antibody Sigma, Anti-γ-Aminobutyric acid
MDL number:
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

GB-69, monoclonal

contains

15 mM sodium azide

species reactivity

wide range

technique(s)

dot blot: suitable
immunofluorescence: suitable
immunohistochemistry: 1:100-1:200 (Using heat-retrieved formalin-fixed, paraffin-embedded human brain and/or cerebellum sections.)
indirect ELISA: suitable

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Gabra1(14394)

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This Item
SAB4200721A2052S5768
Gene Information

mouse ... Gabra1(14394)

Gene Information

human ... GABRA1(2554)
mouse ... Gabra1(14394)
rat ... Gabra1(29705)
rhesus monkey ... Gabra1(574302)

Gene Information

rat ... Gabra1(29705)

Gene Information

human ... SYP(6855)
rat ... Syp(24804)

antibody form

ascites fluid

antibody form

purified from hybridoma cell culture

antibody form

affinity isolated antibody

antibody form

ascites fluid

species reactivity

wide range

species reactivity

rat, monkey, frog, mouse, human, gerbil

species reactivity

rat, Drosophila, wide range

species reactivity

pig, rat, human, guinea pig

conjugate

unconjugated

conjugate

-

conjugate

unconjugated

conjugate

unconjugated

biological source

mouse

biological source

mouse

biological source

rabbit

biological source

mouse

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General description

γ-Aminobutyric acid (GABA) functions as an inhibitory neurotransmitter in the central nervous system. It also functions as a neuromodulator in some peripheral tissues. Additionally, GABA is present in non-nervous tissues and regulates blood pressure, heart rate, respiration, immunomodulation, cell proliferation, protein synthesis and metabolism.
Monoclonal Anti-GABA (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. The antibody does not cross react with L-α-aminobutyric acid, L-glutamic acid, L-aspartic acid, glycine, δ-aminovaleric acid, L-threonine, L-glutamine, taurine, putrescine, L-alanine and carnosine. However, weak cross-reaction is observed with β-alanine and ε-aminocaproic acid.
Monoclonal Anti-GABA (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system and a neuromodulator in certain peripheral tissues. GABA is also present in non-nervous structures.

Immunogen

GABA (γ-aminobutyric acid) conjugated to BSA

Application

Monoclonal Anti-GABA antibody produced in mouse has been used in immunohistochemistry and immunocytochemistry.

Biochem/physiol Actions

γ-Aminobutyric acid (GABA) mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Physical form

Supplied as ascites fluid with 15 mM sodium azide as preservative.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Newborn horizontal cells migrate bi-directionally across the neuroepithelium during retinal development
Edqvist PHD and Hallbook F
Development, 131(6), 1343-1351 (2004)
Structure, function, and modulation of GABAA receptors
Sigel E and Steinmann ME
The Journal of Biological Chemistry, 287(48), 40224-40231 (2012)
GABA may be a neurotransmitter in the vertebrate peripheral nervous system
Jessen KR, et al.
Nature, 281(5726), 71-71 (1979)
Christine J Huh et al.
eLife, 5 (2016-10-18)
Aging is a major risk factor in many forms of late-onset neurodegenerative disorders. The ability to recapitulate age-related characteristics of human neurons in culture will offer unprecedented opportunities to study the biological processes underlying neuronal aging. Here, we show that
Teruyuki Fukushima et al.
Journal of neurophysiology, 102(3), 1459-1471 (2009-04-17)
Analgesic effects of serotonin (5-hydroxytryptamine [5-HT]) type 3 (5-HT3) receptors may involve the release of gamma-aminobutyric acid (GABA) in the spinal dorsal horn. However, the precise synaptic mechanisms for 5-HT3 receptor-mediated spinal analgesia are not clear. In this study, we

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