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A5472

Sigma-Aldrich

Formalin Free Tissue Fixative

greener alternative
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solution

greener alternative product characteristics

Designing Safer Chemicals
Learn more about the Principles of Green Chemistry.

color

colorless

density

1.044 g/cm3

application(s)

hematology
histology

greener alternative category

storage temp.

room temp

Application

A formalin-free tissue fixative that is a less toxic alternative to formalin. Performs well with PCR, in-situ hybridization and immunohistological staining.

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has Inherently Safer Chemistry, compared to the standard use of formalin for tissue processing.

Other Notes

Alcoholic solution with hydroxylated compounds. The product is ready to use and requires no dilution or preparation.

pictograms

Flame

signalword

Warning

hcodes

Hazard Classifications

Flam. Liq. 3

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

118.0 °F

flash_point_c

47.8 °C


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M E Boon et al.
Biotechnic & histochemistry : official publication of the Biological Stain Commission, 83(6), 261-277 (2008-11-26)
The German, F. Blum, introduced formalin as a fixative in 1893. Formalin rapidly became popular for hardening and preserving gross human and animal specimens. As a result, microscopy for diagnostic pathology by combining paraffin embedding and formalin fixation was developed.
Mee Kum Kim et al.
Journal of Korean medical science, 23(5), 864-869 (2008-10-29)
To compare the stem niche in different culture conditions of limbal epithelial cells, the suspended human limbal epithelial cells (HLECs) were seeded on the 3T3-pretreated plates and the other suspended cells were plated on amniotic membranes (AMs) which were either
Hannelore Kothmaier et al.
Archives of pathology & laboratory medicine, 135(6), 744-752 (2011-06-03)
Formalin-fixed, paraffin-embedded tissue is the routine processing method for diagnostics practiced in pathology departments worldwide. To determine the potential value of non-cross-linking, formalin-free tissue fixation for diagnostics in pathology and proteomic investigations. We tested 3 commercially available, formalin-free tissue fixatives-FineFIX
R Scott Pearsall et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(19), 7082-7087 (2008-05-08)
Diseases that affect the regulation of bone turnover can lead to skeletal fragility and increased fracture risk. Members of the TGF-beta superfamily have been shown to be involved in the regulation of bone mass. Activin A, a TGF-beta signaling ligand

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