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A9210

Sigma-Aldrich

Annexin V FITC Conjugate from human placenta

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Synonym(s):
Annexin V, Calphosbindin I, Lipocortin V, PAP-1
NACRES:
NA.32

form

buffered aqueous solution

Quality Level

extent of labeling

1-2 mol FITC per mol annexin V

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... ANXA5(308)

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This Item
A9460SRP8026SAB56000324
Annexin V from human placenta ≥90% (SDS-PAGE), buffered aqueous solution

A9460

Annexin V from human placenta

Sigma-Aldrich

SRP8026

Annexin V human

Quality Level

300

Quality Level

200

Quality Level

-

Quality Level

200

storage temp.

2-8°C

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

wet ice

shipped in

dry ice

shipped in

wet ice

shipped in

wet ice

extent of labeling

1-2 mol FITC per mol annexin V

extent of labeling

-

extent of labeling

-

extent of labeling

-

UniProt accession no.

P08758

UniProt accession no.

P08758

UniProt accession no.

P08758

UniProt accession no.

Application

For detection of apoptotic cells by flow cytometry or fluorescence microscopy.

Biochem/physiol Actions

Annexins are ubiquitous homologous proteins that bind phospholipids in the presence of calcium. The cellular changes involved in the apoptotic process include loss of phospholipid asymmetry during the early stages. This phenomenon is universal and is not limited to stimulus or to mammalian cells, but also occurs in insect and plant cells. In living cells, phosphatidylserine is transported to the inside of the lipid bilayer by the Mg2+ATP dependent enzyme, aminophospholipid translocase. At the onset of apoptosis, phosphatidylserine becomes translocated to the external surface of the cell membrane. Since the movement of phosphatidylserine from the internal membrane surface to the external surface is an early indicator of apoptosis, annexin V and its conjugates that interact strongly and specifically with phosphatidylserine may be used to detect apoptosis. Annexin V conjugates can be used to detect apoptotic cells significantly earlier than DNA-based assays. Fluorescent dye labeled annexin V have applications in flow cytometry, fluorescence microscopy, and laser scanning cytometry.

Packaging

Package size based on protein content

Physical form

Solution in 50 mM Tris-HCl, pH 7.5, containing 100 mM NaCl.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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