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D0676

Sigma-Aldrich

Dobutamine hydrochloride

≥98%

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Synonym(s):
(±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride
Empirical Formula (Hill Notation):
C18H23NO3 · HCl
CAS Number:
Molecular Weight:
337.84
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98%

form

powder

originator

Eli Lilly

storage temp.

2-8°C

SMILES string

Cl[H].CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2

InChI

1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H

InChI key

BQKADKWNRWCIJL-UHFFFAOYSA-N

Gene Information

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This Item
H85021224507D2954000
Dobutamine hydrochloride ≥98%

D0676

Dobutamine hydrochloride

Dopamine hydrochloride

H8502

Dopamine hydrochloride

Dobutamine hydrochloride United States Pharmacopeia (USP) Reference Standard

1224507

Dobutamine hydrochloride

Dobutamine hydrochloride European Pharmacopoeia (EP) Reference Standard

D2954000

Dobutamine hydrochloride

assay

≥98%

assay

-

assay

-

assay

-

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

originator

Eli Lilly

originator

-

originator

-

originator

-

Gene Information

human ... ADRB1(153), ADRB2(154)

Gene Information

human ... ADRB1(153)

Gene Information

human ... ADRB1(153), ADRB2(154)

Gene Information

human ... ADRB1(153), ADRB2(154)

Application

Dobutamine hydrochloride has been used:
  • to treat mouse embryonic fibroblasts for cell death analysis
  • to inhibit TAZ (transcriptional coactivator with PDZ-binding motif)/YAP (Yes-associated protein) of Hippo pathway and study its effect on tumor cell proliferation
  • as β1-AR partial agonist to determine its effects on budding of endophilin-mRFP-positive structures by live-cell imaging

Biochem/physiol Actions

Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation markHealth hazard

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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