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F3004

Sigma-Aldrich

Fetuin from fetal bovine serum

lyophilized powder

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Synonym(s):
Fetuin from fetal calf serum
CAS Number:
EC Number:
MDL number:
NACRES:
NA.32

biological source

bovine serum (fetal)

Quality Level

form

lyophilized powder

technique(s)

HPLC: suitable
MALDI-MS: suitable

impurities

~0.2% free N-acetylneuraminic acid

UniProt accession no.

storage temp.

2-8°C

Gene Information

bovine ... FETUB(504615)

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This Item
F2379A4612F3385
Fetuin from fetal bovine serum lyophilized powder

F3004

Fetuin from fetal bovine serum

Fetuin from fetal bovine serum lyophilized powder, suitable for cell culture

F2379

Fetuin from fetal bovine serum

Bovine Serum Albumin lyophilized powder, Essentially fatty acid free

A4612

Bovine Serum Albumin

Fetuin from fetal bovine serum lyophilized powder, BioReagent, suitable for cell culture

F3385

Fetuin from fetal bovine serum

biological source

bovine serum (fetal)

biological source

bovine serum (fetal)

biological source

bovine

biological source

-

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

UniProt accession no.

Q58D62

UniProt accession no.

Q58D62

UniProt accession no.

P02769

UniProt accession no.

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

impurities

~0.2% free N-acetylneuraminic acid

impurities

≤0.3% free N-acetylneuraminic acid

impurities

≤0.01% free fatty acid (GC)

impurities

≤0.3% free N-acetylneuraminic acid

General description

Fetuin is an abundant glycosylated protein from fetal bovine serum and functions as a transport and storage protein. It is also called the α2-Heremans-Schmid glycoprotein (AHSG) and corresponds to a molecular weight of 64 kDa. It belongs to the statin family and is synthesized principally in the liver and partially in the kidneys, placenta and the tongue.

Application

Fetuin from fetal bovine serum has been used:
  • as a standard glycoprotein in matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) and high-performance liquid chromatography-fluorescence detection analysis (HPLC-FLD)
  • as a ligand in carbohydrate binding assay of pertussis toxin vaccine
  • in the synthesis of fetuin-A conjugated gold nanoparticles (F-GNPs) for drug carrier studies

Biochem/physiol Actions

In humans, polymorphism in the fetuin gene is implicated in type 2 diabetes mellitus and modulates adipocyte functionality. Elevated level of fetuin is observed in obesity and nonalcoholic fatty liver diseases (NAFLD). Fetuin is a potential marker in clinical diagnosis of metabolic disorders.

Preparation Note

Further processing of F2379 by gel filtration.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Fast purification of glycans and glycopeptides using silk-packed micropipette tip for matrix-assisted laser desorption/ionization-mass spectrometry and high-performance liquid chromatography-fluorescence detection analysis
Kayili H, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 139(2), 492-499 (2018)
Iqra Munir et al.
International journal of biological macromolecules, 101, 131-145 (2017-03-23)
Present study was conducted to establish the interaction of bovine fetuin-A to validate its binding modalities with doxorubicin (Dox). Fetuin-A was purified to highest purity and monodispersity. Green synthesis of fetuin-A conjugated gold nanoparticles (F-GNPs) has been performed giving typical
S R Fereidouni et al.
Veterinary microbiology, 135(3-4), 253-260 (2008-11-26)
Accurate identification of hemagglutinin (HA) and neuraminidase (NA) subtypes of influenza A viruses is an integral part of monitoring programs targeting avian influenza viruses (AIV). Use of highly sensitive molecular screening methods such as pan influenza-specific real-time RT-PCR (rRT-PCR) yields
Fetuin-A-Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 1. Fetuin-A as a Calcium Chaperone and Inflammatory Marker
Komsa-Penkova RS, et al.
Journal of Biomedical and Clinical Research, 10(2), 90-97 (2017)
Fetuin-A (alpha2HS-glycoprotein) is a major serum adhesive protein that mediates growth signaling in breast tumor cells
Sakwe AM, et al.
Test, 285(53), 41827-41835 (2010)

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