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H1635

Sigma-Aldrich

N-Hippuryl-His-Leu hydrate

powder, ≥98% (HPLC)

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Synonym(s):
N-Benzoyl-Gly-His-Leu, N-Hippuryl-L-histidyl-L-leucine hydrate
Empirical Formula (Hill Notation):
C21H27N5O5 · xH2O
CAS Number:
Molecular Weight:
429.47 (anhydrous basis)
Beilstein:
5664178
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

acetic acid: ~50 mg/mL

storage temp.

−20°C

SMILES string

O.CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)c2ccccc2)C(O)=O

InChI

1S/C21H27N5O5.H2O/c1-13(2)8-17(21(30)31)26-20(29)16(9-15-10-22-12-24-15)25-18(27)11-23-19(28)14-6-4-3-5-7-14;/h3-7,10,12-13,16-17H,8-9,11H2,1-2H3,(H,22,24)(H,23,28)(H,25,27)(H,26,29)(H,30,31);1H2/t16-,17-;/m0./s1

InChI key

NWOJMNXIJBZMPK-QJHJCNPRSA-N

Gene Information

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This Item
H4884H6750H2508
Hippuryl-Lys

Sigma-Aldrich

H6750

Hippuryl-Lys

Hippuryl-Arg carboxypeptidase substrate

Sigma-Aldrich

H2508

Hippuryl-Arg

form

powder

form

powder

form

powder

form

powder

color

white to off-white

color

-

color

-

color

-

solubility

acetic acid: ~50 mg/mL

solubility

acetic acid: 50 mg/mL, clear, colorless to very faintly yellow

solubility

water: 50 mg/mL, clear, colorless

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

Amino Acid Sequence

NBz-Gly-His-Leu

Application

N-Hippuryl-His-Leu hydrate has been used in the measurement of angiotensin-converting enzyme (ACE) inhibitory activity using oyster hydrolysates, semimembranosus muscle samples, and rabbit lung acetone powder.

Biochem/physiol Actions

N-Hippuryl-His-Leu hydrate (HHL) can be used as an artificial substrate for angiotensin-converting enzyme (ACE).

Substrates

Substrate for angiotensin converting enzyme.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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