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P1784

Sigma-Aldrich

Pentoxifylline

solid

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Synonym(s):
3,7-Dimethyl-1-(5-oxohexyl)xanthine, Trental
Empirical Formula (Hill Notation):
C13H18N4O3
CAS Number:
Molecular Weight:
278.31
EC Number:
MDL number:
PubChem Substance ID:

form

solid

Quality Level

color

white

solubility

H2O: ≥43 mg/mL, colorless to almost colorless

originator

Sanofi Aventis

SMILES string

CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C

InChI

1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3

InChI key

MQGNNJQTNFHNHK-UHFFFAOYSA-N

Gene Information

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This Item
D5385D5314P9689
Pentoxifylline solid

P1784

Pentoxifylline

1,7-Dimethylxanthine ~98%, solid

D5385

1,7-Dimethylxanthine

Sigma-Aldrich

D5314

DPQ

Propentofylline solid

P9689

Propentofylline

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

-

solubility

H2O: ≥43 mg/mL, colorless to almost colorless

solubility

ethanol: 0.6 mg/mL, H2O: 1 mg/mL, 0.1 M NaOH: 2 mg/mL

solubility

DMSO: 1 mg/mL, clear, colorless to faintly yellow

solubility

H2O: 12.4 mg/mL

color

white

color

white

color

-

color

white

originator

Sanofi Aventis

originator

-

originator

-

originator

-

Gene Information

human ... ADORA2B(136), LITAF(9516), PDE4B(5142), TNF(7124)
rat ... Tnf(24835)

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369)

Gene Information

-

Gene Information

human ... ADORA1(134), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)

Application

Pentoxifylline has been used:
  • used in the combinatorial treatment with itraconazole for paracoccidioidomycosis (PCM)
  • to treat harvested sperms to check the effect of ′pentoxifylline exposed sperms′ in the contribution of embryonic growth
  • to intrathecally inject female and male mice to investigate whether astrocytes and microglia could be causally involved in the maintenance of pain-like behaviour

Biochem/physiol Actions

Pentoxifylline (PTX) is considered as a nonspecific phosphodiesterase inhibitor. It possesses rheologic properties. Pentoxifylline is used to treat peripheral vascular disease. It has the ability to block the phosphorylation of I kappa B-alpha (IĸBα) in serines 32 and 36.
Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Synthesis and Metabolism and Phosphodiesterases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Addition of the immunomodulator pentoxifylline (PTX) to antimonial treatment of mucosal leishmaniasis has shown increased efficacy. This randomized, double-blind, placebo-controlled trial evaluated whether addition of pentoxifylline to meglumine antimoniate (MA) treatment improves therapeutic response in cutaneous leishmaniasis (CL) patients. Seventy-three
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Reproductive Biomedicine Online, 32, S11-S11 (2016)

Articles

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

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