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P2533

Sigma-Aldrich

Poly-L-ornithine hydrochloride

suitable for ligand binding assays, Mol wt 15,000-30,000

Synonym(s):

L-Ornithine homopolymer hydrochloride

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About This Item

CAS Number:
26982-21-8
MDL number:
MFCD00166412
UNSPSC Code:
12352209
PubChem Substance ID:
24898334
NACRES:
NA.26

product name

Poly-L-ornithine hydrochloride, mol wt 15,000-30,000

form

powder or solid

Quality Level

200

mol wt

15,000-30,000

technique(s)

ligand binding assay: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

Cl.NCCCC(N)C(O)=O

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Application

Poly-L-ornithine hydrochloride has been used as a substrate analog of acetyl-poly-L-lysine to study substrate binding and catalysis of the NAD-dependent protein deacetylase Hst2. It has been used to bind alginate-polycation-alginate (APA) microcapsules.

Biochem/physiol Actions

Poly-L-ornithine is a polycationic synthetic amino acid polymer. It boosts nasal absorption of hydrophilic macromolecular drugs. Poly-L-ornithine is a specialized coating that acts as a charge modifier.

Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hierarchical Structure Formation of Cylindrical Brush Polymer?Surfactant Complexes
Cong, Y. et al.
Langmuir, 25, 6392-6397 (2005)
Kun Luo et al.
Journal of integrative neuroscience, 20(3), 529-539 (2021-10-15)
Rab3a, a subtype protein in the Rab3 family amongst the small G proteins, is closely associated with the learning and memory formation process. Various neuronal stimuli can induce the expression of Rab3a; however, how DNA modification is involved in regulating
Use of Substrate Analogs and Mutagenesis to Study Substrate Binding and Catalysis in the Sir2 Family of NAD-dependent Protein Deacetylases*
Ahlia N
The Journal of Biological Chemistry (2006)
Emmanuel C. Opara
Methods in Molecular Biology (2017)
Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer
Yusuke K
Biologicals : Journal of the International Association of Biological Standardization (2017)
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Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

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