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P4538

Sigma-Aldrich

Poly-L-ornithine hydrobromide

suitable for cell culture, Mol wt 5,000-15,000

Synonym(s):

L-Ornithine homopolymer hydrobromide

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About This Item

CAS Number:
27378-49-0
MDL number:
MFCD00237231
UNSPSC Code:
12352209
NACRES:
NA.26

product name

Poly-L-ornithine hydrobromide, mol wt 5,000-15,000

form

powder

Quality Level

200

mol wt

5,000-15,000

technique(s)

cell culture | mammalian: suitable

color

white to off-white

storage temp.

−20°C

InChI

1S/C5H12N2O2.BrH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H

InChI key

GWRQMKDBBHFVIZ-UHFFFAOYSA-N

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Application


  • Thermodynamic Characterization of Polypeptide Complex Coacervation.: The research investigates the thermodynamic properties of polypeptide complex coacervation, including the role of Poly-L-ornithine hydrobromide in these interactions. This study provides insights into the self-assembly processes of polypeptides, which are crucial for designing new biomaterials (Priftis et al., 2012).

Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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E Ramsay et al.
International journal of pharmaceutics, 210(1-2), 97-107 (2001-02-13)
The impetus to develop non-viral gene delivery vectors has led to examination of synthetic polycationic polymers as plasmid DNA (pDNA) condensing agents. Previous reports have highlighted superiority (up to x 10-fold) in the in-vitro transfection of pDNA complexes formed by
Electrophoretic deposition of chiral polymers and composites.
Wang Y, Pang X, Zhitomirsky I.
Colloids and Surfaces, B: Biointerfaces, 87, 505-509 (2011)
J P McQuilling et al.
Transplantation proceedings, 43(9), 3262-3264 (2011-11-22)
Severe hypoxia caused by a lack of vascular supply and an inability to retrieve encapsulated islets transplanted in the peritoneal cavity for biopsy and subsequent evaluation are obstacles to clinical application of encapsulation strategies for islet transplantation. We recently proposed
E Ramsay et al.
Journal of drug targeting, 10(1), 1-9 (2002-05-09)
Gene transfer vectors formed between the cationic polyamino acid, poly-(L)-omithine (PLO) and plasmid DNA (pDNA) have demonstrated superior transfection efficiency (up to x 10-fold) compared to equivalent polylysine-based systems in-vitro. The mechanism(s) underlying this observation remains to be elucidated. We
A R Boccaccini et al.
Journal of the Royal Society, Interface, 7 Suppl 5, S581-S613 (2010-05-28)
Electrophoretic deposition (EPD) is attracting increasing attention as an effective technique for the processing of biomaterials, specifically bioactive coatings and biomedical nanostructures. The well-known advantages of EPD for the production of a wide range of microstructures and nanostructures as well
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Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

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