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PZ0365

Sigma-Aldrich

CP-376395 hydrochloride

≥98% (HPLC)

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Synonym(s):
4-Pyridinamine, N-(1-ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-, hydrochloride (1:1), CP376395 hydrochloride, N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenox y)-4-pyridinamine hydrochloride
Empirical Formula (Hill Notation):
C21H30N2O · HCl
CAS Number:
Molecular Weight:
362.94
MDL number:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

SMILES string

CC1=C(NC(CC)CC)C=C(C)N=C1OC2=C(C)C=C(C)C=C2C.[H]Cl

InChI

1S/C21H30N2O.ClH/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5;/h10-12,18H,8-9H2,1-7H3,(H,22,23);1H

InChI key

UDIOZDHQQNYISB-UHFFFAOYSA-N

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Show Differences

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CP-376395 hydrochloride ≥98% (HPLC)

PZ0365

CP-376395 hydrochloride

PF-04455242 hydrochloride ≥98% (HPLC)

PZ0206

PF-04455242 hydrochloride

PF-04363467 hydrochloride ≥98% (HPLC)

PZ0354

PF-04363467 hydrochloride

PF-06412154 hydrochloride ≥98% (HPLC)

PZ0333

PF-06412154 hydrochloride

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage condition

desiccated

storage condition

desiccated

storage condition

-

storage condition

-

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 5 mg/mL (clear solution, warmed)

solubility

H2O: 3 mg/mL, clear (warmed)

solubility

DMSO: 20 mg/mL, clear

Biochem/physiol Actions

CP-376395 is a potent and selective antagonist of the CRF1 receptor, which has been shown to play an important role in mediating behavioral and endocrine responses to fear and stress.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Andrew S Dore et al.
Current molecular pharmacology, 10(4), 334-344 (2017-02-12)
The structural analysis of class B G protein-coupled receptors (GPCR), cell surface proteins responding to peptide hormones, has until recently been restricted to the extracellular domain (ECD). Corticotropin-releasing factor receptor type 1 (CRF1R) is a class B receptor mediating stress
Yuhpyng L Chen et al.
Journal of medicinal chemistry, 51(5), 1385-1392 (2008-02-22)
An orally active clinical candidate of corticotropin-releasing factor 1 (CRF 1) antagonist 1 showed a significant positive food effect in dog and human after oral administration. Efforts to address the food effect issue led us to explore and discover compounds
Jeffrey A Simms et al.
Addiction biology, 19(4), 606-611 (2013-02-01)
Corticotrophin-releasing factor (CRF) is a mediator of stress responses and a key modulator of ethanol-mediated behaviors. We report here that the CRF receptor 1 (CRF-R1) antagonist, CP-376395 reduces 20% ethanol consumption in animals trained to consume ethanol on an intermittent

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