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S4521

Sigma-Aldrich

Saponin Quillaja sp.

Sapogenin content 20-35 %

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CAS Number:
EC Number:
MDL number:
NACRES:
NA.32

description

non-ionic

Quality Level

composition

Sapogenin content, 20-35%

technique(s)

HPLC: suitable
protein quantification: suitable

sulfated ash

≤10%

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This Item
S7900SAE007347036
Saponin Quillaja sp. Sapogenin content 20-35 %

S4521

Saponin Quillaja sp.

Saponin from quillaja bark Sapogenin content ≥10 %

S7900

Saponin from quillaja bark

Saponin

SAE0073

Saponin

Sigma-Aldrich

47036

Saponin

description

non-ionic

description

non-ionic

description

non-ionic

description

-

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

composition

Sapogenin content, 20-35%

composition

Sapogenin content, ≥10%

composition

Sapogenin content, 20-35%

composition

Sapogenin, 8-25%

sulfated ash

≤10%

sulfated ash

<20%

sulfated ash

≤10%

sulfated ash

-

General description

Saponins are steroid or triterpenoid glycosides. They are biosurfactants that have several uses in the food and cosmetic industry.

Application

Saponin from Quillaja bark has been used:
  • to stain fertilized oocytes
  • in the analysis of intracellular cytokine production
  • to permeabilize dendritic cells

Biochem/physiol Actions

Saponins solubilize the low density lipoprotein (LDL) fraction of cholesterol in micelles, thus lowering their concentration. Saponin from Quillaja bark is used as a flavoring agent in food and beverages. This saponin has been shown to enhance immune-cell proliferation in vitro.
Potent hemolytic when injected i.v.; surfactant that enhances penetration of proteins and other macromolecules through cell membranes; it also has been used as an adjuvant for vaccines.

Preparation Note

Purified to remove low molecular weight contaminants 

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Isolation of myeloid and plasmacytoid dendritic cells from human bronchoalveolar lavage fluid.
Tsoumakidou M
Immunology and Cell Biology, 84(3), 267-273 (2006)
Yvonne Lange et al.
Biochemistry, 48(36), 8505-8515 (2009-08-07)
A few membrane-intercalating amphipaths have been observed to stimulate the interaction of cholesterol with cholesterol oxidase, saponin and cyclodextrin, presumably by displacing cholesterol laterally from its phospholipid complexes. We now report that this effect, referred to as cholesterol activation, occurs
Subset-dependent modulation of dendritic cell activity by circovirus type 2.
Vincent IE
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Dynamic chromatin modifications characterise the first cell cycle in mouse embryos.
Santos F
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Adjuvant effects of saponins on animal immune responses.
Rajput ZI
Journal of Zhejiang University. Science. B, 8(3) , 153-161 (2007)

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