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SAB4301136

Sigma-Aldrich

Anti-c-Myc Tag antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
Myc Tag Antibody, Myc Tag Antibody - Anti-c-Myc Tag antibody produced in rabbit, c- Myc epitope Tag
NACRES:
NA.43

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

55 kDa

concentration

1 mg/mL

technique(s)

western blot: 1:1000-1:5000 (Cell Lysate)

isotype

IgG

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

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This Item
M4439F2047SAB4501941
biological source

rabbit

biological source

mouse

biological source

mouse

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

purified from hybridoma cell culture

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

shipped in

wet ice

shipped in

dry ice

shipped in

dry ice

shipped in

wet ice

concentration

1 mg/mL

concentration

~2 mg/mL

concentration

5 μg/mL (suitable for immunoflourescence)

concentration

~1 mg/mL

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

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General description

c-Myc (v-myc avian myelocytomatosis viral oncogene homolog) is a transcription factor, which is coded by MYC gene. It was first described as a homolog of an avian retroviral oncogene. It belongs to the family of transcription factors which are characterized by basic region helix-loop-helix/leucine zipper. Along with N-Myc and L-Myc, it forms the MYC proto-oncogene family. It forms a heterodimer with MAX, and this heterodimer binds to the E-boxes/CACGTG sequence motif on DNA. This gene is localized to human chromosome 8q24.

Specificity

The antibody detects transfected proteins contanining c-Myc Tag.

Immunogen

Synthetic peptide: C-EQKLISEEDL conjugated with KLH.

Application

Anti-c-Myc Tag antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

v-myc avian myelocytomatosis viral oncogene homolog belongs to MYC family. When overexpressed, these proteins can delay the resolution of DNA lesions and cause DNA double-strand breaks (DSBs) and genome instability. This transcription factor MYC helps in regulating long noncoding RNAs (lncRNAs), which has been implicated in cancer cell proliferation and tumorigenesis. Its overexpression is also associated with various cancers, and in particular B cell lymphomas. Elevated expression of c-MYC inhibits the ability of B cell lymphomas to functionally present antigens/peptides to CD4+ T cells. It is associated with Burkitt lymphoma and a group of diffuse large B-cell lymphoma (DLBCL).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1


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MYC impairs resolution of site-specific DNA double-strand breaks repair.
Ambrosio S, et al.
Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis, 774, 6-13 (2015)
Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas.
Seo A N, et al.
British Journal of Cancer, 110(11), 2688-2688 (2014)
Suniti Misra et al.
Frontiers in cell and developmental biology, 9, 649862-649862 (2021-06-22)
Discoveries in the identification of transcription factors, growth factors and extracellular signaling molecules have led to the detection of downstream targets that modulate valvular tissue organization that occurs during development, aging, or disease. Among these, matricellular protein, periostin, and cytoskeletal
Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis.
Kim T, et al.
Journal of the National Cancer Institute, 107(4), dju505-dju505 (2015)
Expression profiles of MYC protein and MYC gene rearrangement in lymphomas.
Chisholm K M, et al.
American Journal of Surgical Pathology, 39(3), 294-303 (2015)

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