MilliporeSigma
All Photos(1)

Documents

SBR00021

Sigma-Aldrich

Nisin Ready Made Solution

(20,000-40,000 IU/mL in 0.02N HCl)

Sign Into View Organizational & Contract Pricing

Synonym(s):
Nisaplin
Empirical Formula (Hill Notation):
C143H230N42O37S7
CAS Number:
Molecular Weight:
3354.07

biological source

Lactococcus lactis

form

solution

concentration

(20,000-40,000 IU/mL in 0.02N HCl)

density

1.02 g/mL

antibiotic activity spectrum

Gram-positive bacteria

mode of action

cell membrane | interferes

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=C(N[C@H](C(NC(C(N[C@@H](CCCCN)C(O)=O)=O)=C)=O)C(C)C)[C@@H](NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@@H](NC([C@H](CC1=CN=CN1)NC2=O)=O)CS[C@H]([C@@H]3C(N[C@H]2CS[C@H]([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC4=O)=

InChI

1S/C143H230N42O37S7/c1-24-69(11)105(148)135(213)162-82(27-4)118(196)174-94-58-225-59-95(175-123(201)89(48-67(7)8)169-115(193)74(16)158-138(216)107(70(12)25-2)180-132(94)210)133(211)184-112-79(21)229-61-96(160-104(190)56-152-134(212)100-38-34-44-185(100)142(112)220)128(206)164-84(36-29-32-42-145)120(198)182-109-76(18)226-60-97(161-103(189)55-151-117(195)85(39-45-223-22)165-122(200)88(47-66(5)6)168-113(191)72(14)156-102(188)54-153-136(109)214)129(207)171-92(51-101(147)187)125(203)166-86(40-46-224-23)119(197)163-83(35-28-31-41-144)121(199)183-110-77(19)228-63-99-130(208)170-90(49-80-52-149-64-154-80)124(202)176-98(62-227-78(20)111(141(219)177-99)181-116(194)75(17)159-140(110)218)131(209)173-93(57-186)127(205)179-108(71(13)26-3)139(217)172-91(50-81-53-150-65-155-81)126(204)178-106(68(9)10)137(215)157-73(15)114(192)167-87(143(221)222)37-30-33-43-146/h27,52-53,64-72,75-79,83-100,105-112,186H,15-16,24-26,28-51,54-63,144-146,148H2,1-14,17-23H3,(H2,147,187)(H,149,154)(H,150,155)(H,151,195)(H,152,212)(H,153,214)(H,156,188)(H,157,215)(H,158,216)(H,159,218)(H,160,190)(H,161,189)(H,162,213)(H,163,197)(H,164,206)(H,165,200)(H,166,203)(H,167,192)(H,168,191)(H,169,193)(H,170,208)(H,171,207)(H,172,217)(H,173,209)(H,174,196)(H,175,201)(H,176,202)(H,177,219)(H,178,204)(H,179,205)(H,180,210)(H,181,194)(H,182,198)(H,183,199)(H,184,211)(H,221,222)/b82-27-

InChI key

NVNLLIYOARQCIX-GSJOZIGCSA-N

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SRE0095SRE0093R6265
Nisin Ready Made Solution (20,000-40,000 IU/mL in 0.02N HCl)

SBR00021

Nisin Ready Made Solution

EcoR I from Escherichia coli BS5 Restriction Enzyme

R6265

EcoR I from Escherichia coli BS5

mode of action

cell membrane | interferes

mode of action

-

mode of action

-

mode of action

-

form

solution

form

aqueous solution

form

aqueous solution

form

buffered aqueous glycerol solution

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

concentration

(20,000-40,000 IU/mL in 0.02N HCl)

concentration

300000-400000 units/mL

concentration

100000-200000 units/mL

concentration

10,000 units/mL

biological source

Lactococcus lactis

biological source

-

biological source

-

biological source

-

application

Due to its wide range of antimicrobial activity, nisin is used as a shelf-life extender in a broad range of dairy and non-dairy products.

Biochem/physiol Actions

Nisin (Nisaplin) is produced by Lactococcus lactis. It is an effective lantibiotic peptide bactericidal agent. Nisin is a broad spectrum antimicrobial bacteriocin which affects Gram-positive bacteria, however, it has little or no effect on Gram-negative bacteria, yeasts or fungi.

It was demonstrated that nisin has capability to inhibit the growth of almost all tested Gram-positive beer-spoilage bacteria. Of 122 Gram-positive bacteria strains (predominantly Lactobacilli and Pediococci), 93% were sensitive to 100 units of nisin. In contrast, out of the 32 Gram-negative strains tested, only the genus Flavobacter proved to be affected by nisin.

Nisin exerts its antimicrobial activity by binding to lipid II which is a membrane-bound advanced intermediate involved in the biosynthesis of bacterial cell wall. By doing so, nisin sequesters lipid II from its functional location. In addition, the nisin-lipid II complex leads to formation of pores in the membrane causing cell death.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 7

1 of 7

Artemisinin 98%

Sigma-Aldrich

361593

Artemisinin

Natamycin VETRANAL®, analytical standard

Supelco

32417

Natamycin

Aspirin meets USP testing specifications

Sigma-Aldrich

A2093

Aspirin

Bacitracin from Bacillus licheniformis, ≥65 IU/mg

Sigma-Aldrich

B0125

Bacitracin

Ampicillin sodium salt

Sigma-Aldrich

A9518

Ampicillin sodium salt

W-Y Cao et al.
Beneficial microbes, 11(1), 67-78 (2020-02-19)
Fibroblast growth factor 21 (FGF21), a metabolism regulator, has an important effect on metabolic diseases, such as obesity and diabetes. It is also expressed in mice, and the murine source has high homology with human FGF21. Recently, it has been
Lantibiotic nisin: Natural preservative from Lactococcus lactis
Suganthi, V.; et al.
International Research Journal of Pharmacy, 1, 13-19 (2012)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service